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Pharmacology > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

What is the MOA of antipsychotics

A

D2 receptor antagonists

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2
Q

What is the pharmacokinetic profile of antipsychotics

A

highly lipophilic, large Vd, long half life, may takes weeks to achieve maximal response

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3
Q

What is a high potency 1st gen drug

A

haloperidol

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4
Q

What is a low potency 1st gen drug

A

chlorpromazine

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5
Q

What are features of high potency 1st gen drugs

A

higher risk of EPSE lower sedation

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6
Q

What are features of low potency 1st gen drugs

A

lower EPSE risk, higher sedation.

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7
Q

What is the prototype second gen drug

A

clozapine

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8
Q

What are reasons for using second gen drug

A

recalcitrant schizophrenia, suicidal behavior
failure of other antipsychotic drugs due to agranulocytosis
absent of EPSE

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9
Q

What are the 5-HT2A> D2 agonists (4)

A

risperidone, olanzapine, quetiapine, ziprasidone

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10
Q

Which drug is a D2 receptor partial agonist

A

ariprazole (Abilify)

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Pharmacology (35 decks)

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