Cancer drugs

Question 1

non cell cycle specific agents

Answer 1

genotoxic agents

Question 2

s phase agents

Answer 2

anti metabolites

Question 3

mitosis agents

Answer 3

cycloskeletal inhibitors

Question 4

g2 phase agents

Answer 4

topoisomerase 1 and 2 inhibitors

Question 5

g1 phase agents

Answer 5

steroid hormones

Question 6

genotoxic agent moa

Answer 6

bind to dna inhibiting replication and causing apoptosis

Question 7

examples of genotoxic agents

Answer 7

ciplatin
carboplatin
oxaliplatin
doxorubicin

Question 8

general action of antimetabolites

Answer 8

inhibit production of nucleic acids

Question 9

examples of antimetabolites

Answer 9

folate antagonists
purine antagonists
pyrimidine antagonists

Question 10

examples of folate antagonists

Answer 10

methotrexate

Question 11

examples of purine antagonists

Answer 11

mercaptopurine

thioguanine

Question 12

examples of pyrimidine antagonists

Answer 12

5 fluorouracil

cytarabine

Question 13

folate antagonist moa

Answer 13

inhibit dihydrofolate reductase

Question 14

5 fluorouracil moa

Answer 14

inhibit thymidylate synthase

Question 15

what do you have to give with folate antagonists

Answer 15

folinic acid to reduce myelosuppression (bone marrow suppresion)

Question 16

what is needed for purine antagonists metabolism

Answer 16

thiopurine methyltransferase

Question 17

examples of cytoskeletal inhibitors

Answer 17

taxanes

vinca alkaloids

Question 18

taxane moa

Answer 18

affect depolymerization in anaphase

Question 19

vinca alkaloids moa

Answer 19

affect polymerization in metaphase

Question 20

examples of taxanes

Answer 20

paclitaxel

docdtaxel

Question 21

example of vinca alkaloids

Answer 21

vincristine
vimblastin
vindesine

Question 22

how do topoisomerase inhibitors work

Answer 22

interfere with topoisomerase enzymes that catalyzes breaking and rejoining of phosphodiesterase backbone of dna causing breaks causing apoptosis

Question 23

top 1 inhibitors

Answer 23

topotecan

irinotecan

Question 24

top 2 inhibitors

Answer 24

etoposide

teniposide

Question 25

selective estrogen receptor modulators

Answer 25

tamoxifen raloxefin toremifene

Question 26

selective estrogen recepto modulators moa

Answer 26

bind to estrogen receptor to prevent growth associated with estrogen

Question 27

tamoxifen metabolism

Answer 27

cyp2d6 metabolism

Question 28

aromatse inhibitors

Answer 28

exemestane anastrozole letrozole

Question 29

aromatase inhibitor moa

Answer 29

blocks final step in estrogen synthesis

Question 30

specific androgen receptor modulators

Answer 30

flutamide | bicalutamide

Question 31

specific androgen receptor modulator moa

Answer 31

competitively binds to androgen receptor