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Pharmacology part B > Cancer drugs > Flashcards

Cancer drugs Flashcards

1
Q

non cell cycle specific agents

A

genotoxic agents

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2
Q

s phase agents

A

anti metabolites

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3
Q

mitosis agents

A

cycloskeletal inhibitors

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4
Q

g2 phase agents

A

topoisomerase 1 and 2 inhibitors

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5
Q

g1 phase agents

A

steroid hormones

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6
Q

genotoxic agent moa

A

bind to dna inhibiting replication and causing apoptosis

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7
Q

examples of genotoxic agents

A

ciplatin
carboplatin
oxaliplatin
doxorubicin

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8
Q

general action of antimetabolites

A

inhibit production of nucleic acids

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9
Q

examples of antimetabolites

A

folate antagonists
purine antagonists
pyrimidine antagonists

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10
Q

examples of folate antagonists

A

methotrexate

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11
Q

examples of purine antagonists

A

mercaptopurine

thioguanine

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12
Q

examples of pyrimidine antagonists

A

5 fluorouracil

cytarabine

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13
Q

folate antagonist moa

A

inhibit dihydrofolate reductase

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14
Q

5 fluorouracil moa

A

inhibit thymidylate synthase

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15
Q

what do you have to give with folate antagonists

A

folinic acid to reduce myelosuppression (bone marrow suppresion)

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16
Q

what is needed for purine antagonists metabolism

A

thiopurine methyltransferase

17
Q

examples of cytoskeletal inhibitors

A

taxanes

vinca alkaloids

18
Q

taxane moa

A

affect depolymerization in anaphase

19
Q

vinca alkaloids moa

A

affect polymerization in metaphase

20
Q

examples of taxanes

A

paclitaxel

docdtaxel

21
Q

example of vinca alkaloids

A

vincristine
vimblastin
vindesine

22
Q

how do topoisomerase inhibitors work

A

interfere with topoisomerase enzymes that catalyzes breaking and rejoining of phosphodiesterase backbone of dna causing breaks causing apoptosis

23
Q

top 1 inhibitors

A

topotecan

irinotecan

24
Q

top 2 inhibitors

A

etoposide

teniposide

25
Q

selective estrogen receptor modulators

A

tamoxifen
raloxefin
toremifene

26
Q

selective estrogen recepto modulators moa

A

bind to estrogen receptor to prevent growth associated with estrogen

27
Q

tamoxifen metabolism

A

cyp2d6 metabolism

28
Q

aromatse inhibitors

A

exemestane
anastrozole
letrozole

29
Q

aromatase inhibitor moa

A

blocks final step in estrogen synthesis

30
Q

specific androgen receptor modulators

A

flutamide

bicalutamide

31
Q

specific androgen receptor modulator moa

A

competitively binds to androgen receptor

Pharmacology part B (17 decks)

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