Cancer Drugs

Question 1

Rescue for methotrexate

Answer 1

Leucovirin

Question 2

Inhibits thymidilate synthase

Answer 2

5 FU

Question 3

“Rescue” for 5 FU

Answer 3

Uridine

Question 4

Causes panyctopenia and cerebellar dysfunction

Answer 4

Cytarabine

Arabynofuranosyl cytidine

Question 5

Decreases de novo purine synthesis

Answer 5

Azathioprine
6MP
6TG

Question 6

Drug for SLE

Answer 6

Azathioprine

Question 7

Increased toxicity with allopurinol

Answer 7

Azathioprine

6MP

Question 8

Uses for Dactinomycin

Answer 8

Wilma tumor
Ewing sarcoma
Rhabdomyosarcoma

Question 9

Causes cardio toxicity

Answer 9

Doxorubicin

Trastuzumab

Question 10

Causes pulmonary fibrosis

Answer 10

Bleomycin

Busulfan

Question 11

Drugs for testicular CA

Answer 11

Bleomycin
Ego posive
Vinblastine

Question 12

Causes hemorrhagic cystitis

Answer 12

Cyclophosphamide

Question 13

Antidote for cyclophosphamide

Answer 13

Mesna

Question 14

Crosses the BBB

Answer 14

Nitrosoureas-carmustine, lomustine, semustine, steptozocin

Question 15

Acts on the M phase

Answer 15

Vinca alkaloids

Taxols

Question 16

Causes neurotoxicity

Answer 16

Vincristine

Question 17

Acts on the M phase and causes bone marrow suppression

Answer 17

Vinblastine

Question 18

For ovarian and breast CA

Answer 18

Paclitaxel and other taxols

Question 19

Hyperstabilize polymerized microtubule a in M phase

Answer 19

Paclitacel and another taxols

Question 20

Causes Nephrotoxicity and acoustic nerve damage

Answer 20

Cisplatin, carboplatin

Question 21

Prevent Nephrotoxicity through scavenging free radicals

Answer 21

Amifostine

Question 22

Inhibits topoisomerase II - DNA degradation

Answer 22

Etoposide, teniposide

Question 23

Inhibits topoisomerase I - prevent DNA unwinding and replication

Answer 23

Irinotecan, topotecan

Question 24

For colon CA

Answer 24

Irinotecan

Question 25

For small cell lung CA

Answer 25

Topotecan

Question 26

Inhibits ribonucleotide reductase - decreases DNA synthesis

Answer 26

Hydroxyurea

Question 27

Selective estrogen receptor modulator

Answer 27

Tamoxifen, raloxifen

Question 28

For breast CA, causes endometrial CA

Answer 28

Tamoxifen

Question 29

Prevents osteoporosis

Endometrial antagonist

Answer 29

Raloxifen

Question 30

Monoclonal antibody against HER 2

Answer 30

Trastuzumab (Herceptin)

Question 31

Tyrosine kinase inhibitor of bcr-abl and c-kit

Answer 31

Imatinib (Gleevec)

Question 32

Treatment for CML and GIST

Answer 32

Imatinib

Question 33

Monoclonal antibody against CD 20

Answer 33

Rituximab

Question 34

Treatment for NHL, RA, ITP

Answer 34

Rituximab

Question 35

Causes progressive multifocal leukoencephalopathy

Answer 35

Rituximab

Question 36

Treatment for metastatic melanoma

Answer 36

Vemurafenib

Question 37

Monoclonal antibody against VEGF

Answer 37

Bevacizumab

Question 38

Inhibits dihydrofolate reductase

Answer 38

Methotrexate