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Pharmacology > Autocoids > Flashcards

Autocoids Flashcards

1
Q

Examples of 1st Generation H1 receptor antagonist

A 
Diphenhydramine
Chlorpheniramine
Cyclizine
Meclizine
Promethazine
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2
Q

Examples of 2nd generation H1 receptor antagonist

A 
Cetirizine
Loratadine
Fexofenadine
Desloratadine
Terfenadine
Astemizole

Note: no autonomic or anti-motion sickness effect unlike the 1st generation anti-histamine

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3
Q

What is the drug interaction between azoles/erythromycin and terfenadine/astemizole

A

fatal arrythmia

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4
Q

Examples of H2 receptor antagonist which is used in the reduction of gastric acid secretion?

A

Cimetidine
Ranitidine
Famotidine
Nizatidine

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5
Q

What H2 receptor antagonist that can cause gynecomastia?

A

Cimetidine

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6
Q

What is the drug of choice for acute migraine?

A

Sumatriptan, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan

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7
Q

What is the mechanism of action of sumatriptan?

A

Inhibits 5-HT1D/1B in the braindrugs

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8
Q

What is a 5HT2 receptor antagonist that is used in the treatment of migraine and cluster headache?

A

Ergotamine, Dihydroergotamine, Methysergide

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9
Q

What is a 5HT2 receptor antagonist that can cause retroperitoneal fibrosis?

A

Methysergide

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10
Q

What is a 5HT2 receptor antagonist that is used in postpartum bleeding?

A

Ergonovine, Methylergonovine

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11
Q

What is a prostaglandin E1 analog that is used in the treatment of peptic ulcer disease and NSAID induced gastric mucosal injury?

A

Misoprostol

Gemeprost

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12
Q

What is the teratogenic effect of Misoprostol?

A

Mobius sequence

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13
Q

What is a prostaglandin E1 analog used in the maintenance of patent ductus arteriosus and used in treating erectile dysfunction?

A

Alprastodil

MOA: activates EP receptors causing vascular smooth muscle relaxation and vasodilation

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14
Q

What is the side effect of the prostaglandin E1 analog used in the maintenance of patent ductus arteriosus?

A

Priapism

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15
Q

What is a Prostaglandin F2alpha analog used in controlling postpartum hemorrhage

A

CARBAPROST
Bimatoprost
Travoprost
Unoprostone

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16
Q

What is a prostaglandin E2 receptor analog used in cervical ripening for induction of labor

A

DINOPROSTONE

Sulprostone

17
Q

What is a prostaglanding I1 analog used in the treatment of pulmonary hypertension and reduces platelet aggregation in dialysis machines

A

ENOPROSTENOL
Beraprost
Iloprost
Treprostinil

18
Q

What is a prostaglandin F2alpha analog used in the treatment of glaucoma (increases outflow of aqueous humor and reduces intraocular pressure)?

A

LATANOPROST
Bimatoprost
Travoprost
Unoprostone

19
Q

What are examples of short-acting beta2-selective receptor agonist used in the treatment of asthma?

A 
ALBUTEROL/SALBUTAMOL
Levalbuterol
TERBUTALINE
Metaproterenol
Pirbuterol
Procaterol
Fenoterol
20
Q

What are examples of long-acting beta2-selective receptor agonist?

A

Salmeterol
Formoterol
Celeneterol
Bambuterol

21
Q

What is a muscarinic receptor antagonist use d in the treatment of asthma by prevetning vagal-stimulated vagoconstriction?

A

Ipratropium, Tiotropium

22
Q

What drugs are phosphodiesterase inhibitors and adenosine receptor antagonists used in the treatment of asthma?

A

Theophylline (Narrow therapeutic window)
Aminophylline
Pentoxifylline

23
Q

Examples of mast cell stabilizers used in the treatment of asthma

A

Cromolyn
Nedocromil
Lodoxamide

24
Q

What is the drug of choice for asthma anaphylaxis?

A

Fluticasone

Similar drugs: Beclomethasone, Budesonide, Ciclesonide, Flunisolide, Mometasone, Triamcinolone

25
Q

What is the mechanism of action of steroids in treating asthma?

A

Phospholipase A2 inhibitor

26
Q

What is the side effect of fluticasone?

A

Oropharyngeal candidiasis

27
Q

what is the treatment for severe refractory asthma (status asthmaticus)

A

IV hydrocortisone

28
Q

What is the steroid that has the lowest systemic steroid toxicity?

A

Ciclesonide

29
Q

What is a leukotriene synthesis inhibitor which acts by inhibiting 5-lipooxygenase and which is used as asthma prophylaxis and in the treatment of exercise, antigen, and aspirin-induced bronchospasm?

A

Zileuton

30
Q

Examples of leukotriene antagonist which acts by blocking cysteinyl leukotriene-1 receptor for Leukotrienes C4, D4 and E4

A

Monteleukast, Zafirlukast, Pranlukast

31
Q

What is a rare side effect of leukotriene antagonists?

A

Churg-Strauss Syndrome

allergic angiits and granulomatous invovlement in the lung, associated with eosinophilia

32
Q

What is a drug that acts as an anti-IgE antibody?

A

Omalizumab

Pharmacology (13 decks)

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