Cancer Chemotherapy Flashcards
Define the objective of adjuvant chemotherapy.
To improve chances for a cure or prolong the period of disease-free when no detectable cancer is present but a number of subclinical neoplastic cells is suspected.
Define the objective of neoadjuvant therapy.
It’s to reduce the tumor burden to allow more effective surgical removal.
How is anticancer-induced bone marrow depression avoided?
By co-administration of erythropoietin, thrombopoietin and GCSF (Filgrastim)
What are the specific side effects of cyclophosphamide?
Cystitis and immunosuppression.
What are the side effects of L-Asparaginase?
Allergy and pancreatitis.
Bleomycin and Busulfan have specific side effects. Mention.
Pulmonary toxicity and fibrosis.
Doxorubicin causes toxicity of which organ?
Heart.
What are the side effects of Vincristine?
Neurotoxicity.
What are the side effects of cisplatin?
Nephro/hepato/neurotoxicity.
What are the side effects of methotrexate?
Immunosuppression and nephrotoxicity.
Antimetabolites work maximally at which phase of the cell cycle?
S phase
What’s Leucoverine and why is it given with methotrexate?
Folinic acid. Given to decrease the incidence of megaloblastic anemia.
Cyclophosphamide belongs to which group of cytotoxic drugs?
Alkylating agents.
How is bleomycin different from other anticancer antibiotics?
All of them are cell cycle nonspecific except bleomycin.
Mention 2 endocrine agents used in treatment of prostate cancer.
GnRH (Leuprolide) and Estrogen
What’s BCG vaccine used for besides its main use?
Prostate cancer
Trastuzumab is..? And used for treatment of..?
A monoclonal antibody against HER2
Used in treatment of HER2 +ve cancers like breast cancer
Bevacizumab is..? Used in treatment of?
Monoclonal antibody against VEGF used as adjuvant treatment of many cancers
What’s the drug that is given with dexamethasone in treatment of multiple myeloma?
Thalidomide.
Mention a CTLA4 inhibitor.
Ipilimumab
Mention PD1 inhibitors.
Pembrolizumab and Nivolumab
Mention PDL1 inhibitors.
Atezolizumab and Durvalumab.
What’s Rituximab used for?
Monoclonal antibody against CD20 on B cell used in treatment of RA and B cell lymphoma.
