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Pharmacology (Multisystem) > Cancer Chemotherapy > Flashcards

Cancer Chemotherapy Flashcards

1
Q

Define the objective of adjuvant chemotherapy.

A

To improve chances for a cure or prolong the period of disease-free when no detectable cancer is present but a number of subclinical neoplastic cells is suspected.

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2
Q

Define the objective of neoadjuvant therapy.

A

It’s to reduce the tumor burden to allow more effective surgical removal.

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3
Q

How is anticancer-induced bone marrow depression avoided?

A

By co-administration of erythropoietin, thrombopoietin and GCSF (Filgrastim)

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4
Q

What are the specific side effects of cyclophosphamide?

A

Cystitis and immunosuppression.

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5
Q

What are the side effects of L-Asparaginase?

A

Allergy and pancreatitis.

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6
Q

Bleomycin and Busulfan have specific side effects. Mention.

A

Pulmonary toxicity and fibrosis.

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7
Q

Doxorubicin causes toxicity of which organ?

A

Heart.

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8
Q

What are the side effects of Vincristine?

A

Neurotoxicity.

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9
Q

What are the side effects of cisplatin?

A

Nephro/hepato/neurotoxicity.

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10
Q

What are the side effects of methotrexate?

A

Immunosuppression and nephrotoxicity.

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11
Q

Antimetabolites work maximally at which phase of the cell cycle?

A

S phase

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12
Q

What’s Leucoverine and why is it given with methotrexate?

A

Folinic acid. Given to decrease the incidence of megaloblastic anemia.

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13
Q

Cyclophosphamide belongs to which group of cytotoxic drugs?

A

Alkylating agents.

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14
Q

How is bleomycin different from other anticancer antibiotics?

A

All of them are cell cycle nonspecific except bleomycin.

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15
Q

Mention 2 endocrine agents used in treatment of prostate cancer.

A

GnRH (Leuprolide) and Estrogen

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16
Q

What’s BCG vaccine used for besides its main use?

A

Prostate cancer

17
Q

Trastuzumab is..? And used for treatment of..?

A

A monoclonal antibody against HER2

Used in treatment of HER2 +ve cancers like breast cancer

18
Q

Bevacizumab is..? Used in treatment of?

A

Monoclonal antibody against VEGF used as adjuvant treatment of many cancers

19
Q

What’s the drug that is given with dexamethasone in treatment of multiple myeloma?

A

Thalidomide.

20
Q

Mention a CTLA4 inhibitor.

A

Ipilimumab

21
Q

Mention PD1 inhibitors.

A

Pembrolizumab and Nivolumab

22
Q

Mention PDL1 inhibitors.

A

Atezolizumab and Durvalumab.

23
Q

What’s Rituximab used for?

A

Monoclonal antibody against CD20 on B cell used in treatment of RA and B cell lymphoma.

Pharmacology (Multisystem) (9 decks)

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