Antifungals Flashcards
How does amphotericin b work?
By binding to ergosterol and making pores through which electrolytes and cell constituents leak.
What’s the parasitic disease amphtericin b is used to treat?
Visceral leishmaniasis
How’s the nephrotoxic effect of amphotericin b overcome?
Bu normal saline infusion or using lipid-based formulas
What’s the type of effect between ketoconazole and amphotericin b?
Antagonistic
What antifungal causes decreased androgen and steroid synthesis?
Ketoconazole.
What’s the antifungal that has no effect on corticosteroid suppression?
Itraconazole
What’s the antifungal of choice in fungal meningitis?
Fluconazole
What’s the antifungal of choice in aspergillosis which also causes visual disturbances?
Voriconazole
What’s the first line treatment in invasive candidiasis?
Echinocandins.
What’s the antifungal which is concentrated in keratinized tissues and is active only against dermatophytes?
Griseofulvin
Mention 2 drugs contraindicated in porphyria.
Barbiturates and Griseofulvin
Which drug is fungistatic against dermatophytes and which is fungicidal?
Fungistatic: Griseofulvin
Fungicidal: Terbinafine
What are the antifungals that are polyene antibiotics?
Amphotericin B and Nystatin
What’s Tolnaftate used for?
Tinea infection. And NOT effective against candida.
