Antituberculous Flashcards
What anti-TB drug is deactylated in the liver? And where is it excreted?
Rifampicin
Excreted in urine and bile.
What’s the chemoprophylactic use of rifampicin?
In meningococcal meningitis
What’s the antituberclous drug that’s a HME inducer?
Rifampicin
Rifabutin is preferred over rifampicin in HIV patients, why?
Because it’s less HME inducer so less drug interactions with anti-HIV drugs.
Rifamixin is preferred over neomycin in which disease?
Hepatic encephalopathy
What’s the antituberculous drug that is acetylated in the liver?
Isoniazid
What’s the mechanism of action of Isoniazid?
Decreases mycolic acid synthesis and decreases utilization of Vit. B6 (Pyridoxine)
What anti-TB drug is a HME inhibitor?
Isoniazid and Fluoroquinolones
What’s the antituberculous drug that is also a MAO inhibitor? And what does it cause with foods containing tyramine?
Isoniazid. It causes hypertension with tyramine containing foods.
What’s the treatment of polyneuritis caused by Isoniazid?
Vit. B6
What’s the anti-TB drug that causes hemolysis in patients with G6PD Deficiency?
Isoniazid.
Mention 2 anti-TB drugs that cause hyperuricemia.
Pyrazinamide and Ethambutol
What anti-tb drug should be given with antacids due to peptic ulceration?
PAS
What drug has the same mechanism as Isoniazid?
Ethionamide
Mention 2 antituberculous drugs that are ototoxic.
Capreomycin and aminoglycosides.
