Antibilharzial & Antihelminthics Flashcards
What’s the mechanism of action of Praziquantel?
It increases calcium influx causing spastic paralysis.
What’s praziquantel active against?
Mansoni, hematobium, H. Nana, heterophyes and taenia.
Oxaniquine and rifampicin have something in common.
Both cause red discoloration of urine.
What’s the mechanism of action of oxaniquine?
Binds DNA and prevents egg deposition.
What’s oxaniquine active against?
Only s. mansoni
All antibilharzials are contraindicated in pregnancy. Yes or No?
Yes.
Metrifonate functions against s. hematobium only, and works by?
Anticholineesterase activity which causes depolarization block and paralysis.
Metrifonate increases the activity of?
Succinylcholine
Oxaniquine is contraindicated in?
Pregnancy and epilepsy
Mebendazole and albendazole are active against?
Ascaris, ancylostoma, enterobius and strongyloides
Pyrental pamoate is active against?
Ascaris, ancylostoma and enterobius.
Levamisole is not only an antihelminthic.
It’s also and immunostimulant used in treatment of colon cancer
What are the drugs used in treatment of leishmaniasis?
Sodium stibogluconate, pentamidine and amphotericin B
