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Blood and Cancer > Cancer Chemo Pharm > Flashcards

Cancer Chemo Pharm Flashcards

1
Q

Cisplatin

A

MOA: cross-linking of DNA
Use: testicular, bladder, lung, colon, ovarian CA
Dose Limiting Tox (DLT): peripheral neuropathy
SAE: ototoxicity, myelosuppression

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2
Q

Cyclophosphamide

A

MOA: alkylation and cross linking of DNA
Uses: leukemias, lymphomas, solid tumors
DLT: myelosuppression
SAE: hemorrhagic cystitis

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3
Q

Cytarabine

A

MOA: inhibitor of DNA polymerase, misincorporation into DNA
Uses: leukemias, lymphomas
DLT: myelosuppression

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4
Q

Fluorouracil

A

MOA: activated to FdUMP which inhibits thymidylate synthetase, also misincorporated into RNA
Uses: colon CA, many solid tumors
DLT: myelosuppression
SAE: GI toxicity

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5
Q

Hydroxyurea

A

MOA: inhibitor of ribonucleotide reductase which is required to convert ribonucleotides to deoxyribonucleotides
USes: melanoma, CML
DLT: myelosuppressionn
SAE: GI toxicity

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6
Q

Methotrexate

A

MOA: DHFR inhibitor
Uses: ALL, choriocarcinoma, lymphomas, many solid tumors
DLT: myelosuppression

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7
Q

Thioguanine

A

MOA: inhibitor of purine metabolism
Uses: acute leukemias, chronic myelocytic leukemia
DLT: myelosupression

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8
Q

Bleomycin

A 
MOA: interacts with DNA and catalyzes free radical formation and DNA 
destruction
Uses: Hodgkin's lymphoma, testicular CA
DLT: Pulmonary fibrosis
SAE: radiation recall, skin lesions
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9
Q

Bevacizumab

A

MOA: antibody against VEGF, inhibits angiogenesis
Uses: epithelial cancers in combo with std therapy
SAE: vascular toxicity ( stroke or MI)

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10
Q

Cetuximab

A

MOA: monoclonal antibody against the extracellular domain of EGFR
Uses: colon cancer, head/neck tumors
SAE: skin lesion

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11
Q

Crizotinib

A

MOA: ALK inhibitor
Uses: non-small lung CA
SAE: bradycardia, visual disturbances

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12
Q

Erlotinib

A

MOA: EGFR inhibitor
Uses: colon CA
SAE: skin lesions

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13
Q

Imatinib

A

MOA: inibitor of ABL, Kit, PDGF-R tyrosine kinases
Uses: CML, GIST
SAE: fluid retension, some myelosuppression

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14
Q

Rituximab

A

MOA: binds to CD20 on the surface of B cells and leads to antibody dependent cellular cytotoxicity
Uses: non-Hodgkin’s lymphoma, B cell leukemias
DLT: myelosuppression
SAE: sensitivity reactions

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15
Q

Sunitinib

A

MOA: inhibitor of RTKs including VEGF-R, PDGF-R, cKit
Uses: inhibits angiogensis and some growth factor dependent tumors, renal cell carcinoma
SAE: vascular toxicity

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16
Q

Trastuzumab

A

MOA: binds to Her2 on cancer cells and stimulates antibody dependent cellular cytotoxicity
Uses: breast CA
SAE: cardiac toxicity

17
Q

Vemurafenib

A

MOA: inhibitor of mutant BRAF kinase
Uses: melanoma
SAE: skin lesions

18
Q

Paclitaxel

A

MOA: binds tubulin and stabilizes microtubules
Uses: ovarian, breast, lung, GI tumors
DLT: myelosuppression
SAE: sensory neuropathy

19
Q

Vincristine

A

MOA: interacts with tubulin and prevents microtubule polymerization
Uses: leukemias, lymphomas, solid tumors
DLT: peripheral neuropathy, myelosuppression

20
Q

Bortezomib

A

MOA: a boronic acid containing dipeptide that inhibits the proteasome and stimulates apoptosis
Uses: multiply myeloma
DLT: peripheral neuropathy, myelosuppression

21
Q

Asparaginase

A

MOA: degrades asparagine in the circulation and starves the tumor cels that cannot synthesize asparagine
Uses: ALL and lymphomas
DLT: hypersensitivity reactions

22
Q

anastrozole

A

MOA: aromatase inhibitor
Uses: post menopausal breast CA
SAE: estrogen withdrawal symptoms

23
Q

Leuprolide

A

MOA: GnRH analog that causes GnRH receptor down-regulation and decreases LH and testosterone
Uses: metastatic prostate, pre-menopausal breast CA
SAE: steroid withdrawal effects

24
Q

Tamoxifen

A

MOA: selective estrogen receptor modulator (SERM) - acts to inhibit ER in breast CA
Uses: pre and post-menopausal breast CA
SAE: estrogen withdrawal symptoms, risk increase for for endometrial CA

25
Q

Dactinomycin

A

MOA: intercalates into DNA and blocks DNA and RNA synthesis
Uses: choriocarcinoma, rhabdomyosarcoma, Wilms
DLT: myelosuppression
SAE: radiation recall

26
Q

Doxorubicin

A

MOA: inhibitor of the topoisomerase II-DNA complex
Uses: lymphomas, breast CA, other solid tumors
DLT: myelosuppression, cardiomyopathy
SAE: radiation recall

27
Q

Etoposide

A

MOA: inhibitor of the topoisomerase II-DNA complex
Uses: testicular, small cell lung, lymphomas, leukemias
DLT: myelosuppression

28
Q

Irinotecan

A

MOA: inhibitor of the topoisomerase I-DNA complex
Uses: colon, ovarian, small cell lung CA
DLT: myelosuppression
SAE: severe diarrhea

Blood and Cancer (11 decks)

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