Blood Pharm

Question 1

Aminocaprioic acid

Answer 1

MOA: lysine analog that competitively binds plasmin and results in inhibition of fibrinolysis
Used for: pro-hemostatic agent
SAE: thrombosis

Question 2

4 factor prothrombin complex concentrates

Answer 2

MOA: Human blood coagulation factor replacement containing factors II, VII, IX, and X
Uses: urgent reversal of acquired co-ag factor deficiency caused by Vit K antagonist therapy
SAE: thrombosis

Question 3

Acetylsalicylic acid

Answer 3

MOA: non-selective, irreversible cyclooxygenase inhibitor
Uses: prevention/treatment of arterial thrombosis, anti-inflammatory
SAE; bleeding, GI toxicity, nephrotoxicity

Question 4

Alteplase

Answer 4

MOA: stimulates conversion of plasminogen to plasmin, activating fibrinolysis
Uses: coronary artery thrombosis, PE, ischemic stroke
SAE: bleeding, esp. cerebral hemorrhage

Question 5

Cyclosporine

Answer 5

MOA: calcineurin inhibitor
Uses: prevention/treatment of graft vs host disease in HSCT; idiopathic acquired aplastic anemia
SAE: HTN, electrolyte wasting, nephrotoxic

Question 6

Dabigatran

Answer 6

MOA: direct thrombin (FII) inhibitor
Uses: stroke prevention in A-fib, DVT, PE
SAE: bleeding, GI disturbances

Question 7

Desmopressin

Answer 7

MOA: vasopressin analog selective for V2 receptors, stimulates release of von Willebrand factor
Uses: von Willebrand disease, qualitative platelet disorder
SAE: hyponatremia

Question 8

Eltrombopag

Answer 8

MOA: thrombopoietein receptor agonist stimulates megakaryocyte/platelet production and hematopoetic stem cells
Uses: chronic idiopathic thrombocytopenia purpura, idiopathic acquired aplastic anemia

Question 9

Enoxaparin

Answer 9

MOA: indirect FXa inhibitor (complexes with antithrombin)
Uses: treatment/prevention of venous thrombosis, acute coronary syndromes
SAE: bleeding, thrombocytopenia (rare)

Question 10

Epoetin alfa

Answer 10

MOA: activate erythropoietin receptor to stimulate red blood cell production
Uses: anemia secondary to cancer, renal disease, IBD
SAE: HTN, thrombosis

Question 11

Filgrastim

Answer 11

MOA: granulocyte colony-stimulating factor analog, stimulates neutrophil production
Uses: neutropenia secondary to chemo or bone marrow transplant
SAE: bone pain

Question 12

Fondaparinux

Answer 12

indirect FXa inhibitor (complexes with antithrombin)
Uses: venous thrombosis prevention/treatment, acute coronary syndromes
SAE: bleeding

Question 13

Hydroxyurea

Answer 13

MOA: inhibitor of ribonucleotide reductase which is required to convert ribonucelotides to deoxyribonucleotides
Uses: myeloproliferative disorders, sickle cell anemia
SAE: cytopenias

Question 14

Imatinib

Answer 14

MOA: inhibitor of ABL, Kit, PDGF-R tyrosine kinases
Uses: chronic myelogenous leukemia, Ph+ALL
SAE: CHF, GI-upset

Question 15

Recombinant FVIIa

Answer 15

MOA: recombinant factor VIIa
Uses: individuals with hemophelia who have antibody inhibitors to coag factors VIII or IX, patients with acquired hemophilia, and those with congenital factor VII deficiency
SAE: thrombosis

Question 16

Rituximab

Answer 16

MOA: binds to CD20 on the surface of B cells and leads to antibody dependent cellular cytotoxicity
Uses: CD20 expressing hematopoietic malignancies, ITP
SAE: infuional reactions, neutropenia

Question 17

Rivaroxaban

Answer 17

MOA: direct factor Xa inhibitor
Uses: stroke prevention in A-fib, DVT, PE
SAE: bleeding

Question 18

Romiplostim

Answer 18

MOA: thrombopoietein receptor agonist, stimulates megakaryocyte/platelet production
Uses: chronic idiopathic thrombocytopenia purpura

Question 19

Unfractionated Heparin

Answer 19

indirect FIIa and FXa inhibitor
Uses: venous thrombosis prevention/treatment, acute coronary syndromes
SAE: bleeding, thrombocytopenia (rare), osteoporosis (with chronic use)

Question 20

Vitamin K

Answer 20

MOA: activation of vit-K dependent clotting factors
Uses: slow reversal of acquired coag factor deficiency induced by Warfarin therapy

Question 21

Warfarin

Answer 21

MOA: inhibits Vit K epoxide reductase blocking production of Vit K dependent clotting proteins (II, VII, IX, X) and Vit K dependent anti-clotting proteins C and S
Uses: stroke prevention in A-fib, DVT, PE, and mechanical heart valves
SAE: bleeding