Cancer Flashcards
Hyperplasia
Increase in the number of cells in an organ or tissue
Metaplasia
Conversion of one type of cell into another
Dysplasia
Bizarre cell growth resulting in cells that differ in shape, size or arrangement from other cells of the same tissue type
Anaplasia
Growth pattern which lacks normal characteristics and differ in shape and organization
Neoplasia/neoplasm
Replacement of damaged tissue
Doubling time
the amount of time it takes for a tumor to double in size by miotic cell divisions
Gene expression
The activation or “turning on” of a specific gene to the extent that it synthesizes specific protein that influences the activity of a cell or group of cells
Gene suppression
The deactivation or “turning off” of a specific gene so that is silent and doesn’t synthesize a protein
Initiation
the damage of a normal cell’s DNA by a carcinogen
Anaplastic
Without shape or differentiation, small and round
Fibronectin
A large, extracellular, transformation-sensitive-cell-surface protein present on normal cells that allows normal cells to adhere tightly together
Latency
The period of time b/w when a carcinogenic agent or substance damaged the DNA of a normal cell and when an overt cancer is present
Cancer
A group of many diseases of multiple causes that can arise in any cell of the body capable of evading regulatory controls over proliferation and differentiation
Initiation in carcinogensis
Carcinogens alter the DNA of the cell. Cell will either die or repair
Promotion in carcinogensis
Repeated exposure to carcinogens. Abnormal gene will express. Latent period.
Progression in carcinogensis
Irreversible period. Cells undergo neoplastic transformation then malignancy