Calculations Flashcards

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1
Q

What is the formula for calculating renal plasma flow (RPF)?

A

RPF = RBF x (1 - Hematocrit) or RPF = (urine [PAH] x V) / plasma [PAH]

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2
Q

How is minute ventilation and alveolar ventilation calculated?

A
  • Minute (L/min) = tidal volume (L) x breaths/min
  • Alveolar (L/min) = (tidal volume - dead space volume) x breaths/min
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3
Q

What is Winter’s formula?

A

Expected PaCO2 = [1.5 x (serum HCO3-) + (8 ± 2)]

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4
Q

Calculation for half-life (t1/2) of drug when given volume of distribution (Vd) and clearance rate (CL)?

A

t1/2 = (0.7 x Vd) / CL

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5
Q

How can you calculated the GFR and the RPF?

A
  • GFR = [U] inulin or creatinine x V / [P] inulin or creatinine
  • RPF = [U]PAH x V / [P]PAH
  • FF = GFR/RPF

*V = urine flow rate (mL/min)

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6
Q

Formula for renal blood flow (RBF)?

A

RBF = RPF / (1 - Hct) or (PAH clearance) / (1 - Hct)

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7
Q

How to calculate SV and use this to calculate EF?

A
  • SV = EDV - ESV
  • EF = SV / EDV = (EDV - ESV) / (EDV)
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8
Q

What is the formula for loading dose and maintenance dose?

A
  • LD = (CP x Vd) / F
  • MD = (CP x CL x t) / F

*CP = Css or target steady state [plasma]

* CL = clearance; t = elapsed time btw doses; F = bioavailability

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