calcium review SDL Flashcards
what % of calcium is found bound to plasma proteins in the blood
40-45 %`
what % of calcium is found within complexes in the blood
5%
what % of calcium in the blood is ionized calcium
50%
How would your interpretation of plasma total calcium concentrations change if the animal suffers from hypoproteinemia?
total would be lower but ionised unchanged. wouldnt interpret low total calcium as necessarily hypocalcemia
what is calcitonin and where is it secreted
opposite action of PTH. made in the parafollicular cells of the thyroid
describe the effects of PTH on phosphorus homeostasis
- prmotes renal loss of phosphorus
- promotes absorption of phosphorus from GI tract
If an animal developed a tumour of the parathyroid gland and was secreting excess amounts of hormone….
1. How would the bone be affected?
2. Would the plasma calcium concentration be high, low, or normal?
3. Would the plasma phosphorous concentration be high, low, or normal?
- promotion of bone resorption (fast and slow)
- increased
- decreased
What are the effects of hyperparathyroidism on calcium and phosphorous excretion in the urine?
calcium retained, phosphorus excreted
What would happen within the body if a tumour was secreting a protein that has the same biological activity as PTH (called PTH-related protein; PTHrp)?
the same would happen for a tumour secreting PTH
What would happen to an animal if it were placed a very high phosphorous diet (containing very little calcium)?
- nutritional secondary hyperparathyroidism
- increased FGF-23
- bone resorption
- rubber jaw
- big head
describe the process of calcitriol-stimulated calcium absorption by intestinal cells
increases production of:
- calcium channel proteins
- calcium binding protein
- calcium ATPase pumps
these increase calcium uptake from the gut
