Buzzwords

Question 1

3rd person auditory hallucinations

Answer 1

schizophrenia

Question 2

mesocortical dopamine hypoactivity

Answer 2

negative and cognitive symptoms in schizophrenia

Question 3

subcortical dopamine hyperactvitiy

Answer 3

psychosis

Question 4

what are the 3 dopamine pathways in the brain

Answer 4

1. tuberoinfundibular- concerned with prolactin release
2. nigrostriatal- extra pyramidal motor movements
3. subcortical and mesocortical- dysregulated in schizophrenia

Question 5

mesolimbic Da blockade and agonism

Answer 5

blockade= depression

agonism= psychosis

Question 6

side effects of clozapine

Answer 6

agranulocytosis
weight gain
cardiomyositis

Question 7

issues surrounding clozapine

Answer 7

need to have tried 2 other anti- psychotis first

consultants to prescribe

monitor once per week for first 6/12 weeks
then once per fortnight for next 6/12 weeks
then once very month there on after

Question 8

limbic system function

Answer 8

(M2OVE)

motivation
memory
olfaction
visceral afferents
emotion

Question 9

brain changes in schizophrenia

Answer 9

reduced frontal lobe volume ( and reduced grey matter)

enlarged lateral ventricles

reduced grey matter in temporal cortex

Question 10

what is pressure of thought

Answer 10

varied ideas in abundance

seen in manic patients

Question 11

what is poverty of thought

Answer 11

patient reports lack or absence of thought

Question 12

abrupt and complete interruption of stream

seen strongly in schizphrenia

Answer 12

thought blocking

Question 13

flight of ideas

Answer 13

quickly moving between topic but there IS a link

Question 14

treatment of EPSE

Answer 14

procyclidine

Question 15

involved in normal response to threat

Answer 15

amygdala

Question 16

dampens down amygdala response to threat

Answer 16

pre frontal cortext

Question 17

OCD management

Answer 17

1. SSRI
2. other SSRI
3. TCA or SSRI
4. SSRI or TCA (cloripramine)

used CBT as adjunct

Question 18

learning difficulties

Answer 18

borderline 70-80 ish

mild 50-59

moderate 35-49

sevre 20-34

profound < 20

Question 19

becks triad

Answer 19

negative feelings about self, world and future

Question 20

NMDA agonists

Answer 20

psychotic symptoms

Question 21

alcohol withdrawel

use what?

Answer 21

use chlordiazepoxide

Question 22

alcohol withdrawel

when do you get seizures

when do you get delirium

Answer 22

seizures within 48 hours

delirium between 48-72 hours

Question 23

Eosinophilic inclusions

Answer 23

lewy bodies

Question 24

risk of hypertensive crisis with MAOIs

Answer 24

treat with Phentolamine infusion

Question 25

avoid TCAs in those with what

Answer 25

heart problems

or in suicidal intent