anti- depressants Flashcards
generally , how do most anti- depressants work?
increase neurotransmitter availability by blocking re-uptake
what do SSRI’s do?
block re-uptake of seretonin
what do TCA’s do?
block re-uptake of seretonin and norepinephrine
what do MAOIs do?
prevent break down of dopamine, norepinephrine and serotonin
what group do these belong to?
citalopram
fluoxetine
paroxetine
SSRI’s
adverse effects of TCA’s?
constipation dry mouth sedative blurry vision urinary retention postural hypotension
name some anticonvulsants that are sometimes used as mood stabilisers
carbamazepine
valproate
lamotrigine
hypertension crisis can occur if your diet isnt controlled whenS taking what medication
MAOIs
cardiot toxic in overdose
TCAs
what do you get seretonin syndrome
high temp agitation sweating tremor brisk reflexes dilated pupils diarrhoea
side effects of SSRI
CNS-tremor, restlessness, insomnia, headache, drowsy
GI- N+V, diarrhoea, cramps, weight loss, sexual dysfunction
CVS- increased HR, seretonin syndrome
when should SSRI’s be avoided/ do they interact with anything?
they inhibit P450 enzymes
so will affect levels of a drug which metabolised by the P450 system
what are these examples of??
venlafaxine
duloxetine
SNRI
what do SNRI’s interact with?
SSRIs and MAOIs
what are these examples of?
amitrypaline
clomipramine
TCA
