Breast pathology 031121 Flashcards
cytopathology staging in breast
c1 - inadequate sample, c2 - benign, c3, atypia, c4- ssuspicious of malignancy, c5 - malignant
what is normal breast histopathology
ductal lobular system
duct ectasia
40-60 year old women, smoking biggest risk factor, inflammation and dilation of large breast ducks, poorly defined palpable periaeolar mass with thick white nipple secretions.cytology protinaeous and macrophages
fat necrosis
painless breast mass, skin thickening, causes, trauma, radiotherapy, surgery, cytology empty spaces, histiocytes and giant cells
fibrocytic disease
different epithelium responses to hromones, breast mouse, young women 20-30, shelling out is curative, fna cytology branching sheets of epithelium, bare bpolar nuclei and stroma
duct papilloma
benign papillary tumour arising within the duct system of breast can lead to tumour so must remove surgically.
radial scar
needs to be exised, stellate sclerosing lesion
types of carcinoma in situ
lobular (always incidental finding on biopsy as no microcalcifications or stromal reactions, 20-40% bilateral, cells lack e-cadherin) and ductal (ducts filled with ATYPICAL epithelial cells.
basal like carcinoma
histologically, often associated with BRCA,
invasie breast carcinoma
ductal, lobular, tubular and mucinus