Breast Lecture- Treatment Flashcards
what are some risk factors for breast cancer
previous breast cancer genetic BRAC1 and BRAC2 HRT oestrogen only alcohol weight
what is the presentation of breast cancer
asymptomatic symptomatic - lump nipple discharge nipple changes lympadenopathy dimpling in the skin
what investigations should you do
history examaintion drugs history mammogram and USS FNA core biopsy of sentinel lymph node FBC x ray
what is the classification of tumour
Tx Primary tumour cannot be assessed T0 Primary tumour not palpable T1 Clinically palpable tumour -size < 2 cm T2 Tumour size 2-5 cm T3 Tumour size > 5 cm T4a Tumour invading skin T4b Tumour invading chest wall T4c Tumour invading both T4d Inflammatory breast cancer
what does n stand for
n0-no regional lymph nodes
n1- regional lymph nodes mobile
n2- regional lymph node palpable-fixed
what does m stand for
mx- distant metastasis not asseses
m0-no
m1-distant metastasis
what is adjuvant treatment
after other initial treatment to prevent relapse
what is neoadjuvnt treatmetn
used to shrink tumour proper to surgery
when is breast conservation surgery appropriate
tumour locally <4
single tumours
what should you do is SLN is positive
remove alll lymph nodes
radiotherapy
whaat is factors associated with reoccurrence
tumour size tumour grade nodes negate PR and ER positive HER
what to treat people with for positbve ER
tamoxifen -teratagenic
zoldex
when is chemo used
grade 3
for younger women
<50
what are examples of chemo
CMF combinations
anthracycline combiantions
taxane based nominations
what is give to HER positive
trastuzumab
