Breast cancer Flashcards
risk factors
personal history of breast cancer genetic mutation BRAC1 BRAC2 FH of breast/ovarian cancer prior breast irradiation at young age childbearing absent or after 30 early periods/late menopause hot high BMI high alcohol intake
fibrocystic changes
associated with what
benign
lumpiness
thickening
swelling
women period
fibroadenomas
who
solid round rubbery lump that moves under the skin when touched - mouse
young women
infections
red, warm, tender, lumpy
micro calcifications
tiny deposits of calcium - majority are harmless
small % may be cancerous
screening
mam
50-70s
every 3 years
what does triple assessment include
clinical exam
imaging
fine needle aspiration/biopsy core
what happens when cancer is confirmed
CT for staging/MRI
radiotherapy following breast conservation surgery - just breast alone
negative sentinel biopsy
noted conning micro metastases 0.2-2mm in SNB
or < 4nodes in an adequate axillary node clearance
radio following breast conservation - boost to tumour bed for women
under 54 on the day of surgery
posterior margin <1mm for invasive disease after full thickness incision
radio following mastectomy - chest wall radio
tumour >5cm
4 or more nodes involved
involved resection margins
T4 disease
radio to ipsilateral axilla
> 1 positive macro metastases sentinel node
extensive ECS post axillary clearance
radio to the supraclavicular fossa
4 or more nodes involved
adjuvant treatment
tamoxifen - 10 years
letrozole - 5 years
who is trastuzumab given to
whose cancer cells express HER2-neu as measured by IHC or FISH
