Brain Development Flashcards

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1
Q

The cells of the nervous system connect with one another in trillions of remarkably specific patterns that form and ) ove rth ecourse of an organisms life

A
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2
Q

These connections develop among various types of neurons process that begins where

A

in the embryo

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3
Q

What is the first step

A

appropriate type sof neurons must arise in appropriate numbers and migrate to appropriate places

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4
Q

The axons and dendrites that form the connection then extend from _____ cells

A

nerve

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5
Q

What must happen to the growth of the axons

A

Must be guided over long distanes so that htey reach the appropriate targets. T

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6
Q

What happens to the connections that form initially then _ with the activity and experience of early posternal life

A

mature

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7
Q

The degree of complexity in the ______ and therefore the amount of interaction required to regulate its development

A
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8
Q

What is the brain to other organs in the body

A

much more complex

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9
Q

Are the initial steps in brain development similar accross the brain?>

A

They are similar, but later become different

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10
Q

What is an example of the brain development?

A

Diseases that are thought to be in the brain

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11
Q

Advances in teh study of bran development hve become increasingly relevent for what?

A

medical treatments

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12
Q

Three to four weeks after conception, one of the two cell layers of the empryo starts to do what?

A

Thicken up and build up along the middle,

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13
Q

As the cells continue to divide and this flat neural plate grows, parallel rides similar to the creases in a paper airplane rise across its

A

surface

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14
Q

When the top of the tube thickens …to makes haat?

A

three bulges that form the hind, mid and forebain

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15
Q

The emryo has three layers that undergo many interactions in order to grow in to what?

A

organ, bone, buscle, skin or neural tissue.

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16
Q

What do skin and neural tissue arise form

A

the ectoderm in response to signals provided ny the adjacent layer

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17
Q

A number of molecules interact to determine whether the ectoderm becomes what?

A

neural tissue or develops in another way to beomc skin

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18
Q

Studies of spinal cord development in forgs show that one major mechanism depends on specific proteins that inhibit

A

the activity of other proteins

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19
Q

IN an area where no inhibition occurs, what happens to the tissue?

A

It becomes skin

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20
Q

IN areas where proteins secreted form the esodern do lead inhibition, what happens to the tissue

A

It becomes neural

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21
Q

What does inhibit mean

A

to block a psycological process

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22
Q

Once the ectodermal tisssue has aquared its neural fate more signaling interactions determing what happen?>

A

What type of brain cell forms. The mature nervous system contains a vast array of cell types which can be divided into two main categories

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23
Q

What can the neurons in the nervous system be divided into?

A

They can be divided into two main categories: neurons responsible for signaling and for uspporting cells called glial cells

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24
Q

Researchers are finding that hte destiny of neural tissue depends on what

A

cell position withi the nervous system that define the environmental signals to which the cels are exposed.

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25
Q

What is a key factor in spinal cord development

A

a secreted protein called osnic hedgehog that is similar to a signaling protein found in flies W

26
Q

When is the protein originally secreted?

A

From mesodermal tissue lying beneath the developing spinal cord, marks directly adjacent neural cells to become specialized class of lial cells

27
Q

Cells that are further away athat are exposed become

A

motor neurons that control muscles.

28
Q

A Combination of signals also determines the type of

A

chemical messages or neurotransmitters that a neuron will use to communicate with other cells.

29
Q

Is the neurotransmitter fixed for nuerons?

A

Some it is fixed, but others it is a matter of choice

30
Q

Neurons are initially produced along the central canal in the

A

neural tube

31
Q

The neurons then migrate form their birthplace to a final destination wher?

A

in teh brain

32
Q

How do the neurons form each of the various brain strucures and acquare specific ways of transmiting nerve messages?

A

They collect together to form various structures

33
Q

What do the axons do?

A

They grow long distances to find and connect with apppropriate partner, forming elaborate and specific circuits.

34
Q

How many neurons arethere

A

100 billion

35
Q

As neurons are produced they move from where to where?

A

form the ventricular zone or inner surface to the near of the marginal zone or outter surface

36
Q

After the neurons stop dividing, whatdo they form>

A

An intermediatezone where they gradually accumulate as the brain develps

37
Q

The migration of neurons occurs in most of the structures of the brian but is prominent in the formation of

A

a large cerebral cotex in primates

38
Q

How do the neurons form the cerebral cortex structure?

A

Neurons slither from the place of origin near the venricular surface, along non neuronal fibers that form a trail to their proper destination

39
Q

What does proper neuron migration require?

A

Multiple mechanims, including the recognition of the proper path and the ability to move long distances

40
Q

What does proper neuron migration require?

A

multiple mechanisms including the recognition of the proper path and the ability to move long distanes

41
Q

One mechanism for long distance migration is the movement of nuerons

A

along elongated fibers that form transietn scaffoling in the fetal brain

42
Q

What external forces can prevent proper neural nigration?

A

alcool, cocaine, or radiation can inhibit

43
Q

Once the neurons reach thier final location, what must htey do?

A

make the proper connections for a particular function to occur-for example vision or hearing, They do this through axons

44
Q

What is an axon’s growth directed by?

A

Cones

45
Q

How do molecules help the cones?

A

Some lie down,and cue the cones that have to move

46
Q

The bining of particular signals with receptors tell the growth cone whether to

A

move forward, stop recoil or change direction

47
Q

What are some signaling molecuels?

A

netrin,semaphorin, and ephrin

48
Q

What is the most remarkable findin about these proteins

A

They are common to many other animal

49
Q

Once axons reach thier targets, what do they form?

A

synapses which permit electirc signals in the acon to jump to th enext cell where htey can either provoke or prevent the generation of a new signal

50
Q

The regulation of these transmisison at synapses and the integration of inputs from the thousands of synapses each neuron recieves

A

are responsible for the astounding information -processing capcaity of th ebrain

51
Q

For processin to occur properly, the connections must be

A

highly speciifc

52
Q

Some specifity arises form the mechaniss that guide

A

guide each acons to its proper targe area

53
Q

Additional molecules mediate target recognition which means

A

the axon chooses THE PROPER NEURON AND OFTEN THE RPOPER PART OF THE TARGET, ONCE IT ARRIVES AT ITS DESTINATION

54
Q

What have researchers also had success in identifying?

A

The ways inwhich the synapse differntiates one conact have been made

55
Q

The tiny porion of the axon that contacts the dendrite becomes s what

A

specialized for the release of the neurotransmitters and the tiny portion of the dendrite that recieves the contact becoms specialized to recieve nad respond to the signal

56
Q

Special molecules pass between the sending and recieving cells to ensure that hte contact is formed properly and that the sending and recieve specializations are

A

precisely matched

57
Q

These processes ensure that the synapse can transmit signlas quickly and effectvely. Finally, other moleculses coordinate the maturation of the synapse after it has formed so that it can occomodate the changes as our bodies mature

A
58
Q

Many axons in the brain require a sheath of mylien to enhance what?

A

The speed of conduction

59
Q
A
60
Q
A