Brain Abscess

Question 1

Brain abscess

Answer 1

Circumscribed enlarging infections

S/s similar to space occupying lesion
But progress more rapidly

Uncommon disorder

Question 2

Risk

Answer 2

Compromised immune:

Systemic illness
Steroid use
Immunosuppressants
Cytotoxic chemo

Question 3

Predominantly occur

Answer 3

Parietal lobe from blood borne infections

Question 4

Otitis and mastoiditis

Answer 4

Temporal lobe and cerebellum

Question 5

Sinusitis

Answer 5

Frontal and temporal lobes

Question 6

Days 1-3

Answer 6

Involvement of cerebrum

Inflammatory infiltrates w/in 24 hours

By 3, increased perivascular inflammation

Question 7

Days 4-9

Answer 7

Center is necrotic

Question 8

10-13

Answer 8

Early astrocytes surround infection and capsule forms

Question 9

14 days - 5 weeks

Answer 9

Necrotic center shrinks, capsule thickens, astrocyte scarring

Question 10

S/S

Answer 10

HA recent onset
High WBC
Expanding intracranial mass
Possible herniation and BS compress

Stiff neck rare, normal body temp common

Question 11

EEG

Answer 11

Abnormal

Question 12

EEG

Answer 12

Abnormal

Question 13

Tx

Answer 13

Antibiotic
Surgical drainage
Monitor CT
Corticosteroids initially for edema

Question 14

Antibiotics and surgery

Answer 14

Lower mortality from 65% to 30%

Question 15

Neurological sequalae

Answer 15

50%

Question 16

Prion disease

Answer 16

Creutzfeldt-Jackie disease

Bovine spongiform encephalopathy

Question 17

Creutzfeldt-Jacob disease

Answer 17

Rare, fatal, degenerative

Familial conditions or cannibalism

Question 18

Bovine spongiform encephalopathy

Answer 18

Mad cow

Consumption of infected beef

Question 19

Prion disease patho

Answer 19

Prion protein programs the normal proteins to change so they are fix similar to the abnormal cells

Question 20

Prion manifest

Answer 20

Movement abnormal
Demetnial worsens over time

Akinetic mutism eventually develop w/ overriding myoclonic jerks

Question 21

Prion dx

Answer 21

Western blot testing

Question 22

Prion disease management

Answer 22

No known to

Rapidly progression and will be fatal