Bordetella pertussis

Question 1

Bordetalla pertussis causes

Answer 1

whooping cough

Question 2

fn of adhesins

Answer 2

bind to cilia. filamentous hemaglutin (Fha) large surface protein forms helical felament

Question 3

pertussis exotoxin ptx

Answer 3

A5B. some bound to bac. surface and used for attachment

Question 4

fn of A subunit

Answer 4

ADP ribosylates the Gi protein, inactives it = increase cAMP. Gi inhibits adenlate cyclase. increase cAMP causes thick mucous inhibts cilia axn

Question 5

define virulence regulon

Answer 5

of genes/operon in which their expression is regulated by one protein

Question 6

virulence regulon of B pertussis

Answer 6

2 componet trandxn sys. bvgs is transme sen kin located PM. detects env signal in perplsm & autoph. then phosh BvgA (cytoplasmic response rgulator) promots trasncription of ptx, fha etc

Question 7

virulence regulon of B pertussis

Answer 7

2 component trandxn sys. bvgs is transme sen kin located PM. detects env signal in perplsm & autoph. then phosh BvgA (cytoplasmic response rgulator) promots trasncription of ptx, fha etc