Antibiotic Bacterial Drugs A)Introduction

Question 1

define antibiotic

Answer 1

compounds produced by fungi or bacteria that kill/inhibit growth of other org. term includes semi synthetic and synthetic drugs also

Question 2

about 1/2 of antibiotics are secreted by bacteria eg

Answer 2

Streptomyces and a few Bacillus

Question 3

Antibiotic spectrum-narrow spectrum targets and eg

Answer 3

limited amount of bacteria. penicillin targets gram +ive bacteria

Question 4

broad spectrum targets and eg

Answer 4

most bacteria. eg Tetracycline

Question 5

selective toxicity goals

Answer 5

to target bacteria w/as little harm to host as possible

Question 6

bacterial targets include

Answer 6

gram -ive OM, peptidoglycan, peptidoglycan synthesis, 70S ribosome, nucleic acid synthesis, and bacterial specific metabolise pathway

Question 7

antibiotic resistance occurs when

Answer 7

bacteria produce enzyme that destroys drugs, alter permeability of drug. alter target of the drug and can’t bind. Efflux bacteria pump drug out before it can reach target