Bones Flashcards
Periosteum
Outer layer of bones, fibrous layer serves as a point for blood vessels and nerves to attach, cellular layer contains mesenchymal stem cells
Osteoblasts
Synthesises osteoid and then deposits calcium hydroxyapatite to form extracellular matrix of bone
Osteocytes
Osteoblasts that got stuck in the bone, monitor the bone, respond to stress levels
Osteoclasts
Destroyers, perform resorption (destruction)
Osteoid
Extracellular matrix, mostly type 1 collagen stuck together by ground substance
Osteon
Functional unit of compact bone, circular structure
Structure of osteon
Layers of rings called lamellae separated by interstitial lamella
Haversian canal
Blood vessels in the centre of osteon
Volkmann canal
Connect Haversian canals with periosteum
Endochondral ossification
Formation of long bones from cartilage template, continued lengthening is by ossification at epiphyseal plates
Intramembranous ossification
Form from clusters of mesenchymal stem cell in the centre of the bone
Cancellous bone conversion to cortical bone
- mesenchymal stem cells differentiate into osteoblasts, lay down osteoid
- Osteoblasts is trapped
- Repeat to form lamellae
- Central MSCs convert into blood vessels, lymph vessels and nerves
Appositional growth
increasing width
5 types of bones
Long, short, flat, irregular, sesamoid
Long bones
- Longer than they are wide
- Support the weight of the body and facilitate movement