bone repair and calcium homeostasis

Question 1

what issues can you get with too much bone resorption?

Answer 1

• osteoporosis
• osteopenia (weak bones but not enough to break)
• rickets

Question 2

what happens when there is too much bone formation?

Answer 2

osteopetrosis

Question 3

what are general classifications of bone?

Answer 3

long and short bones

Question 4

how can we macroscopically classify bones?

Answer 4

cortical bone- dense

calcaneous bone- spongy

Question 5

how can you microscopically classify bone?

Answer 5

woven bone- immature and disorgaised also flexible

lamellar bone- more stress orientated,used to be woven bone but stress makes it organise and get stronger

Question 6

what are the 3 types of bone cells?

Answer 6

osteoblasts – on surface bone, produce protein component acellular matrix – regulate bone growth and degradation

osteocytes – quiescent mature cells embedded in bone matrix. They maintain bone.

osteoclasts – responsible for bone degradation and remodelling

Question 7

what happens to osteocytes as you age?

Answer 7

they go down

Question 8

what do osteocytes orignatte from?

Answer 8

precursor cells in bone marrow