Bollus Skin Disorders Flashcards
Which bullous skin disorder is associated with an anti-basement membrane anti-body?
A. Porphyria cutanea tarda B. Erythema multiforme C. Pemphigus vulgaris D. Dermatitis herpetiformis E. Bullous pemphigoid
āEā
Porphyria Cutanea Tarda
- Deficiency of heme synthetic enzyme
- induced by estrogen or alcohol
- associated with hep C
- elevated copro- and uroporphyrins
- Blisters on sun-exposed skin
- Skin fragility
- Milia
- Hypertrichosis
Porphyria Cutanea Tarda
Tx
- serial phlebotomy, antimalarials
Bullous Pemphigoid
- Large, tense subepidermal bullae
- may see erythematous patches and /or urticarial plaques
- do not spread with lateral shearing
- Mucous membranes infrequently involved
Bullous Pemphigoid
Autoantibodies directed at basement membrane
Bullous Pemphigoid
Associated drugs:
- furosemide
- ibuprofen
- other NSAIDS
- captopril
- penicillamine
Bullous Pemphigoid
Tx Steriods
Pemphigus vulgaris
- thin-walled, flaccid bullae that are easily ruptured
- Erosions frequently present
- Enlarge by confluence
- mucous membranes frequently involved
- Nikolskyvsign - lateral shearing produces blister
Pemphigus vulgaris
mucous membranes frequently involved
Pemphigus vulgaris
Nikolskyvsign - lateral shearing produces blister
Pemphigus vulgaris
Autoantibody to desmosome component
Pemphigus vulgaris
Intra-epidermal split
Pemphigus vulgaris
Tx high dose steroids
Dermatitis Herpetiformis
-Extremely itchy grouped vesicles most frequently located on extensor surfaces
Dermatitis Herpetiformis
Associated with a gluten-sensitive enteropathy
