Body Systems Approach Flashcards
Chemical defenses of the skin
Salt inhibits microbes
Lysozyme hydrolyzes peptidoglycan
Fatty acids inhibit some pathogens
Defensins are antimicrobial peptides
Normal microbiota of the skin
Gram-positive, salt-tolerant bacteria, group into small clumps
Micrococci
Staphylococci
- S. epidermidis
- S. aureus
Diphtheroids (pleomorphic rods)
Some are opportunistic pathogens
Two major genra of bacteria causing skin infections
Staphylococcus
Streptococcus
Staphyloccocal skin infections include
S. epidermidis
- 90% of people have it
- Opportunistic infection (broken skin or catheter)
- Produce biofilm
S. aureus
Most pathogenic of staphylococci
Problem in hospitals (MRSA)
Produce leukocidin - an exfoliative toxin
S. epidermidis infection
Staphylococcal Skin infection
Very common on skin (90%)
Opportunistic infection (broken skin or catheter)
Produce biofilm
S. aurerus skin infection
Most pathogenic of staphylococci
Problem in hospitals (MRSA)
Produce leukocidin - an exfoliative toxin
Kill phagocytes, Resistant to opsonization,
Produces superantigen
Folliculitis
Infections of the hair follicles (often called pimples
stys
furunlce
Carbuncle
Sty
Folliculitis of eyelash
Furuncle
(boil)- localized hair infection
A type of abscess (pus surrounded by inflamed tissue).
Carbuncle
more extensive damage by folliculitis
Inflammation of tissue under the skin
Impetigo
Infectious skin lesions with crusted centers
Mostly affects children (2 to 5 yrs)
Highly contagious
May involve both S. aureus and Streptococcus pyogenes
SSSS
Staphylococcal Scalded Skin Syndrome (SSSS)
In babies (problem in nurseries)
Due to exfoliative toxin
Type of S. aureus infection
Toxic shock syndrome
Often life threatening
Toxin (superantigen) enter the bloodstream
Characterized by high fever, low blood pressure, malaise and confusion, can progress to coma
What drug is often the last line of antimicrobial defense
Vancomyosin
What type of skin infection produces hemolysins
Streptococci
S. pyogenes infection is what genra
Streptococcal Skin Infections
Erysipelas
Reddish patches with raised margins (more superficial)
Treatment for streptococcal infections
(b-lactam-type antibiotics, e.g. cephalosporin)