Body fluids and osmolarity Flashcards
where are body fluids found?
blood plasma
intracellular
interstitial
how much of body weight is water?
60%
how is water content in lean tissue measured
L/Kg
how much of total body water content is found in intracellular space?
40%
– including blood cells
how much of total body water content is found as interstitial fluid?
15%
how much of total body water content is found in plasma space?
5%
what makes up the extracellular space?
Plasma space and interstitial fluid
how much do blood cells and plasma space make up of the blood volume?
8%
what are other fluid compartments found in the body - transcellular fluid?
cerebrospinal fluid aqueous& vitreous humour synovial fluid amniotic fluid GI tract secretions Lymph fluid - these spaces are part of the extracellular space
how to measure fluid compartments (volumes) - dilution method?
- Add known amount of substance (in moles) to an unknown volume
- Measure the concentration (Grams per Litre)
- Volume = (Amount of Substance (Moles))/(Concentration of substance)
what substances can we use to measure fluid compartments?
non Toxic substances
substances that are not metabolised quickly
in the plasma volume somethings that is larges and insoluble as it does not diffuse across capillaries easily
in the extracellular space something that does not enter cells easily
what are the constituents of body fluid?
cations and anions - electrolytes
proteins
dissolved gases, nutrients and metabolites
cells in blood
what is osmolarity?
concentration of a solution expressed as the total number of solute particles per litre - milliosmoles/L
what is osmolality?
concentration of particles per Kg of solution
- milliosmoles/Kg
what are the most abundant ions in body fluids?
sodium, chloride and potassium