BODY FLUIDS Flashcards
Homeostasis
Relative constancy of “millea interieur” (Internal Environment)
millea interieur (Surrounding and Internal Environment)
- Surrounding environment is vastly different from the external environment
- Internal environment remains relatively constant under health conditions
Most abundent single constituent in the body (%)
water (45-75%
Aspects of Body Fluids
Volume, distrobition, characteristics, function
How does body water change with age?
% water decreases (muscle decreases, connective tissue and adipose tissue increases)
Body water % in skin tissues
70%
Body water % in muscle tissues
75%
Body water % in heart, liver, brain, kidney in tissues
70-80%
Body water % in bone tissues
25%
Body water % in fat tissues
10%
Fat tissue is also known as
Adipose tissue
Body water is in a _______ steady state
dynamic
amount of obligatory losses per day
1.5 L / day
What are the two obligatory losses (amounts)
insensible (lungs skin) - 1 L
Urine + stool - 0.5 L
amount of facultative losses per day
vary with intake
What is the facultative loss?
Urine (kidney is a homeostatic organ)
What is insensible perspiration?
Body water lost on a daily basis at a constant rate
What is sweating?
Loss of body fluid due to intense activity …. by sweat glands
Sweating or insensible perspiration: Pure Water (loss)
insensible perspiration
Sweating or insensible perspiration: Passive evaporation (temperature or humidity)
insensible perspiration
Sweating or insensible perspiration: Entire Skin Surface (without sweat glands)
insensible perspiration
Sweating or insensible perspiration: Continous
insensible perspiration
Sweating or insensible perspiration: Electrolyte solution
Sweating
Sweating or insensible perspiration: Active secretion
Sweating
Sweating or insensible perspiration: Sweat glands
Sweating
Sweating or insensible perspiration: activated by heavy work or high temp
Sweating
water balance (adult % / infant %)
turnover of water (2-4% in 24 hrs / 10 % in over 24 hrs)
Body water helps maintain normal ________ and ______ volume / pressure
solute concentration and blood
Body water keeps an adequate supply of ___ to _____
O2 to tissues
Negative Water Balance
More loss than intake
Water intoxication
to much water intake
Negative Water Balance or Water intoxication: Reduced intake
Negative Water Balance
Negative Water Balance or Water intoxication: Excessive loss from gut
Negative Water Balance
Negative Water Balance or Water intoxication: Excessive Gut
Negative Water Balance
Negative Water Balance or Water intoxication: Excessive Loss in Expired Air (high altitudes)
Negative Water Balance
Negative Water Balance or Water intoxication: Excessive loss of urine
Negative Water Balance
Negative Water Balance or Water intoxication: Excessive intake
Water intoxication
Negative Water Balance or Water intoxication: Renal System Failure
Water intoxication
Two Body Water Compartments
Intracellular Fluid ICF and Extracellular Fluid ECF
ICF % of body water
2/3
ECF % of body water
1/3
ICF % of body mass
40%
ECF % of body mass
20%
ICF location (cells)
Inside all the cells
ECF location (cells)
around the cells
ECF two major and minor subcompartments
Major: Plasma and Interstitial fluid (ISF)
Minor: Lymph and Transcellular Fliud
Plasma (def. and % Body mass)
Fluid portion of blood 5%
Interstitial Fluid (def. and % Body mass)
Fluid between individual cells 15%
Lymph (def. and % Body mass)
network of blind-ended terminal tubules <1%
Transcellular Fluid (def. and % Body mass)
Small fluid volumes secreted by specific cells into body cavities (<1-2%)
Buffy Layer of Blood (2)
WBCs, Platelets
RBCs is also known as
Erythrocytes
Hematocrit
(packed cell volume)
Body Fluid compartments are in a (static/dynamic) equilibrium
dynamic
Distribution between compartments = (constant/changing)
constant
Indicator Dilution Method formula
V = Q/ c
Volume
Quantity of indicator
Concentration
Non-toxic, no changes in water between compartments, diffuse readily, distribute evenly, easy to measure
Indicators
Indicator for total body water
Antipyrine D20 T20
Indicator for ECF
radioactively labeled - insulin, sucrose, mannitol
Indicator for plasma
Evans blue
Body fluids are ______ solutions of ______ ions with variable amounts of ________
aqueous, inorganic, protein
the compartment that is High in K+ and Mg 2+, low in Na+ and Cl-
ICF
the compartment that is High in Na+ and Cl-, low in K+ and Mg 2+
ECF
The cell membrane is between the ____ and _____
ICF and ECF
The capillary wall is between the ____ and _____ (2)
ECF and plasma, plasma and external environment
The only thing needed to know for indicator dilution method (2)
(1) The total quantity of test substance introduced
(2) The concentration of the substance/unit volume of fluid, after dispersion