blood infections Flashcards
blood infection disease
bacterial : sepsis&septic shock. rheumatic fever, anthrax, brucellosis,plague,leptospirosis,lyme disease, Q fever.
viral: Burkitt’s lymphoma, mononucleosis, CMV AIDS heaemorrhagic fever
fungi: candidiasis
sepsis and septic shock stage:
- infalmmation and release of cytokines
2. lymphangitis, inflamed lymph vessels
sepsis G- pathogen
E.coli/ Klebsiella/ Pseudomonas
endotoxin
sepsis G+ pathogen
S. aureus. S. pyogenes
potent exotoxins(superantigens). TSST(toxic shock syndrome toxin)
Enterococci(hosptial aquire)
puerperal sepsis pathogen
group A strep: streptococcus pyogenes(b-haemolytic)
puerperal sepsis known as
childbirth or childbed fever
puerperal sepsis infect ___
uterus
anthrax pathogen
bacillus anthracis:
- large aerobic G+ rods . endospore-forming
- affect cattle and sheep
- disease rare in human
three form of anthrax
- cutaneous anthrax—–cantact spore
- gastrointestinal anthrax—–rare. ingest spore
- inhalation( pulmonary anthrax)
anthrax pathogenicity
- exotoxin enzymes:a.Edema factor(EF) b.Lethal factor(LF)
2. PA (protective antigen) binds the toxin to target cells.
brucellosis pathogen
brucella spp
-G- coccobacilli
subacute bacterial endocarditis pathogen
most a-haemolytic streptococci
subacute bacterial endocarditis transmission
dental work
acute bacteral endocarditis pathogen
staphylococcus aureus
rheumatic fever pathogen
strep. pyogenes(Group A)