Blood Development Flashcards
Common myeloid progenitor gives rise to…
Neutrophil
Eosinophil
Basophil
Monocyte
Erythrocyte
orthochromatiphilic erythroblast
2
basophilic erythroblast
Myelocyte - Specific granules (content differs with cell type) produced by rough ER and GC
Pro erythroblast
Polychromatophilic erythroblast
endosteal niche
site for long-term storage of quiescent HSCs, also houses osteoprogenitors cells, osteoblasts and osteoclasts
Blood cell formation occurs in…
the spaces between sinusoids.
reticulocyte
Hematopeoisis location by trimester
1: yolk sac
2: liver
3: Bone Marrow
What do hematopeoitic stem cells yield
myeloid and lymphoid stem cells
Myeloblast - No cytoplasmic granules
Fibronectin, laminin and hemonectin
bind to receptors on developing blood cells, may anchor them to the matrix
common lymphoid progenitor gives rise to…
lymphocytes
Metamyelocyte - Nucleus indents. Many specific granules, few azure granules.
mature blood cells and sinusoids consist of…
reticular fibers, fibronectin, laminin, hemonectin, various collagens, proteoglycans, ground substance
Thrombopeoisis steps
hemocytoblast -> common myeloid progenitor –> CFU mega –> megakaryoblast –> promegakaryocyte –> megakaryocyte (via thrombopoeitin)–> platelet
what is this
Bone marrow TEM
Bone marrow makeup
reticular tissue
megalaryocytes
fat cells
sinusoids
macrophages
vascular niche
blood vessels and surrounding stromal (reticular cells), mesenchymal stem cells, adipocytes, macrophages and endothelial cells.
Promyelocyte - Azure granules (lysosomes) produced in conjunction with the rough ER and Golgi complex
G-CSF growth factor is important for…
neutrophil lineage. The synthetic form of G-CSF (filgrastim or lenograstim) is used for the treatment of neutropenia such as after cancer chemotherapy or bone marrow transplantation.
