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HISTO > Blood Development > Flashcards

Blood Development Flashcards

1
Q

Common myeloid progenitor gives rise to…

A

Neutrophil

Eosinophil

Basophil

Monocyte

Erythrocyte

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2
Q
A

orthochromatiphilic erythroblast

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3
Q

2

A

basophilic erythroblast

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4
Q
A

Myelocyte - Specific granules (content differs with cell type) produced by rough ER and GC

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5
Q
A

Pro erythroblast

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6
Q
A

Polychromatophilic erythroblast

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7
Q

endosteal niche

A

site for long-term storage of quiescent HSCs, also houses osteoprogenitors cells, osteoblasts and osteoclasts

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8
Q

Blood cell formation occurs in…

A

the spaces between sinusoids.

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9
Q
A

reticulocyte

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10
Q

Hematopeoisis location by trimester

A

1: yolk sac
2: liver
3: Bone Marrow

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11
Q

What do hematopeoitic stem cells yield

A

myeloid and lymphoid stem cells

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12
Q
A

Myeloblast - No cytoplasmic granules

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13
Q

Fibronectin, laminin and hemonectin

A

bind to receptors on developing blood cells, may anchor them to the matrix

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14
Q

common lymphoid progenitor gives rise to…

A

lymphocytes

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15
Q
A

Metamyelocyte - Nucleus indents. Many specific granules, few azure granules.

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16
Q

mature blood cells and sinusoids consist of…

A

reticular fibers, fibronectin, laminin, hemonectin, various collagens, proteoglycans, ground substance

17
Q

Thrombopeoisis steps

A

hemocytoblast -> common myeloid progenitor –> CFU mega –> megakaryoblast –> promegakaryocyte –> megakaryocyte (via thrombopoeitin)–> platelet

18
Q

what is this

A

Bone marrow TEM

19
Q

Bone marrow makeup

A

reticular tissue
megalaryocytes
fat cells
sinusoids
macrophages

20
Q

vascular niche

A

blood vessels and surrounding stromal (reticular cells), mesenchymal stem cells, adipocytes, macrophages and endothelial cells.

21
Q
A

Promyelocyte - Azure granules (lysosomes) produced in conjunction with the rough ER and Golgi complex

22
Q

G-CSF growth factor is important for…

A

neutrophil lineage. The synthetic form of G-CSF (filgrastim or lenograstim) is used for the treatment of neutropenia such as after cancer chemotherapy or bone marrow transplantation.

HISTO (14 decks)

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