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OLFU Parasitology > Blood And Tissue Flagellates > Flashcards

Blood And Tissue Flagellates Flashcards

0
Q

Infective stage for 3 species of trypanosoma

A

Metacyclic trypomastigote

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1
Q

Trypanosoma

A

Gambiense
Rhodesiense
Cruzi

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2
Q

Mode of transmission of trypanosoma

A

Bite from blood sucking invertebrates ( glossinia and reduviid )
Ingetion of infected fly
Entrance of parasite through abrasion

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3
Q

Etiologic agent of gAmbian or west african sleeping sickness

A

Trypanosoma gambiense

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4
Q

Trypanosoma gambiense

A

Found in west and central africa

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5
Q

Trypanosoma gambiense form of disease

A

Chronic

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6
Q

Trypanosoma gambiense morphology

A

Polymorphic

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7
Q

Trypanosoma gambiense forms

A

Epimastigote

Trypomastigote

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8
Q

Trypanosoma gambiense vectors

A

Riverine tsetse flies

Glossinia spp

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9
Q

Trypanosoma gambiense infect human during

A

Swimming

Doing laundry

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10
Q

Trypanosoma gambiense pathology

A

CNS involvement, 2nd year death

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11
Q

Trypanosoma gambiense incubation period

A

14 days to months

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12
Q

Trypanosoma gambiense congenital transmission possible

A

True

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13
Q

Trypanosoma gambiense sign and symptoms

A 
Nodule or chancre
Acute: fever, headache, joint pin, microcytic anemia, leukocytoss
Lymphadenopathy
Winterbottom's sifn
Suboccipital lymph node
Chronic: diffuse meningoencepalitis
CNS inolvement ess profound
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14
Q

Enlarged non tender psterior cervcal lymoh nodes

A

Winterbottom’s sign

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15
Q

Etiologic agent of east african sleeping sickness

A

Trypanosoma rhodesiense

Rhodesian trypanosomiasis

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16
Q

Acute type of african sleeping sickness

A

Trypanosoma rhodesiense

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17
Q

Trypanosoma rhodesiense morpholgy

A

Indistinguisabe from gambiense

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18
Q

Lower incidence, less frequent epidemics

A

Trypanosoma rhodesiense

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19
Q

Trypanosoma rhodesiense reservoir

A

Wild animals

Domestic cattles

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20
Q

Trypanosoma rhodesiense vector

A

Woodland tsetse flies ( glossinia moritants, G. Pallidipes )

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21
Q

Trypanosoma rhodesiense pathology

A

More rapid and fatal than gambiense

Death within 1 year

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22
Q

Trypanosoma rhodesiense difference in gambiense

A

Febrile paroxysma

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23
Q

Trypanosoma rhodesiense sign and symptoms

A 
Less pronounced nodule enlargement
Edema
Myocarditis
Weakness
CNS changes ess frequent
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24
Trypanosoma cruzi
Nwe world | American
25
AKA of Trypanosoma cruzi
Chaga's disease
26
Trypanosoma cruzi
Common in S. America
27
Trypanosoma cruzi reservoir
Wild rodents, burrowing animals, mammals
28
Trypanosoma cruzi morphology
All stages present 20 um C or S shaped
29
Trypanosoma cruzi stages
Amastigote Epimastigote Trypomastigote
30
Trypanosoma cruzi blood
Long, thin flagellates
31
Trypanosoma cruzi tissue
Round intracell amastigote, cyst like
32
Trypanosoma cruzi vector
Reduviid bug, triatoma infestation, kissing bug
33
Trypanosoma cruzi pathology
Prefer cardiac, skeletal and muscle fibers for multiplication Found in blood and intracell in early stage
34
Trypanosoma cruzi ss acute
Common among s
35
Local lesion at site of incubation; subcutaneous
Chagoma
36
Unilateral conjuctivitis, orbital edema
Romana's sign
37
Trypanosoma cruzi ss chronic
Megaesophagus Megacolon Alteration in conduction system of heart CHF
38
Leishmania types
Leishmania tropica Leishmania braziliensis Leishmania donovani
39
3 species recognized according to clinical entities
Cutaneos Mucocutaneous Visceral
40
2 morphologic stages leshmania
Amastigote | Promastigote
41
Only human, intracellular in vertebrates
Amastigote
42
Midgut and proviscus in intermediate host, infective stage
Promastigote
43
Leishmania Infective stage to definitive host
Metacyclic promastigote
44
Multiply by binary fission in the macrophage
Meracyclic promastigote
45
Leishmania diagnosis
Visualization of amastigotes in blood smears and bone marrow biopsy Culture growth of promastigotes
46
Leishmania treatment
Donovi, tropica, braziliensis Meglumine antimonite Sodium stibogluconate
47
Leshmania tropica
New world leshmaniasis
48
Cutaneous leishmaniasis
Leshmania tropica
49
Leshmania tropica tropica major
Dry lesion, no exudates
50
Leshmania tropica tropica minor
Wet lesion, more common in urban areas
51
Leshmania tropica reservoir
Gerbils and rodents
52
Leshmania tropica ss
Swelling - papule - pustule - sore - crusted ulcer | Epitheloid and lymphoid
53
Cutaneous leishmaniasis description
``` Most common Oriental sores, jericho boils Sore at the bite site Heal in few months to years Leaves an unpleasant scar Can progress to any 3 forms ```
54
Leishmania braziliensis
Mucocutaneous leishmaniass
55
American leishmaniasis
Leishmania braziliensis
56
Leishmania braziliensis pathology
Lessions occur on skin, oral, nasal and pharynx then erode to form ulcers
57
Leishmania braziliensis forms
Chiclero ulcers, espundia, uta
58
Leishmania braziliensis ss
Ulcers
59
Mucocutaneous leishmaniasis description
More aggressive Last longer Disseminated to mucos membrane ( mouth and nose )
60
Leishmania braziliensis treatment
Pentostam or pyrimethamie | Cycloguanil pamoate
61
Leishmania donovani
Old world leishmaniasis
62
Common in africa, india, asia, midle east
Leishmania donovani
63
Other name of Leishmania donovani
Kala azar ( black sickness )
64
Leishmania donovani aka
Visceral leshmaniasis
65
No nonhuman reservor
Classic kala azar
66
Leishmania donovani dogs
Infantile
67
Resistant to antimony treatment, rats
Sudanese
68
Leishmania donovani vector
Sand fly female | Phlebotomus spp. And lutzomyia
69
Leishmania donovani reservoir
Dogs
70
Leishmania donovani 1st sign and symptoms
Malaise Intermittent fever Headache
71
Leishmania donovani diagnosis
Cultivated in NNN or liquid cultures as promastigote of splenic and hepatic material Blood smear or culture Sternal, splenic, hepatic, or LN puncture

OLFU Parasitology (9 decks)

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