Atrial Flagellates pathogenic Flashcards

0
Q

Habitat of giardia lambia

A

Duodenum
Jejunum
Upper ileum
Upper small intestine

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1
Q

What are synonyms of giardia lambia?

A

Giardia intestinalis
Lambia intestinalis
Giardia duodenalis
Lambia duodenalis

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2
Q

Epidemiology of gardia lambia

A

Most common acquired STD
Worldwide distribution
Prevalence is 6%; 14% under 9 years old
Increase frequency in multiple partner

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3
Q

Transmission of giardia lambia

Most common source of outbreak

A

Water borne

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4
Q

Transmission of giardia lambia

How many cyst the food have to make contaminated?

A

1-10

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5
Q

Transmission of giardia lambia

Homosexual practices

A

Oro-Anal

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6
Q

Giardia lambia also called

A

Traveller’s diarrhea

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7
Q

How many flagella the giardia lambia have?

A

8

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8
Q

Trophozoite G. Lambia

Shape

A

Pyriform or teardrop shaped

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9
Q

Trophozoite G. Lambia

Pyriform or teardrop shaped. Pointed posteriorly with a distinct medial line called

A

Axostyle

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10
Q

Trophozoite G. Lambia

Description

A

Non infective
Baby stage
9-12 um long, 5-15 um wide
Divide by longitudinal binary fission

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11
Q

Trophozoite G. Lambia

Shape,
Dorsal side and ventral side

A

Dorsal- convex

Ventral- concave

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12
Q

Trophozoite G. Lambia

Shape

Anterior and posterior

A

Anterior- round

Posterior- pointed

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13
Q

Trophozoite G. Lambia

Nuclei

A

A pair of ovoidal nuclei, one on each side of midline

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14
Q

Trophozoite G. Lambia

Flagella

A

Arise from the ventral side
3 pairs flowing
1 pair fused

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15
Q

Trophozoite G. Lambia

Movements

A

Slow erratic oscillation or

Falling leaf motility

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16
Q

Cyst G. Lambia

Description

A

Infective

Adult stage

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17
Q

Cyst G. Lambia

Shape

A

Ovoid

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18
Q

Cyst G. Lambia

Nuclei

A

Young cyst - 2 nuclei

Mature cyst- 4 nuclei

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19
Q

Cyst G. Lambia

Flagella

A

Contracted into axonemes

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20
Q

Cyst G. Lambia

Cytoplasm

A

Separated from cyst wall

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21
Q

Cyst G. Lambia

Diagnostic

A

Retracted cytoplasm

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22
Q

Cyst G. Lambia

Resistant to

A

Chlorine and cold water

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23
Q

Gardia lambia

Incubation period

A

1-4 weeks

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24
Q

Gardia lambia

Symptomatic in

A

40% of patients

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25
Q

Gardia lambia

Pathologic changes in the intestinal wall

A
  1. Flattened tips of villi and shallow crypts
  2. Mucosal inflammation
  3. Hyperplasia of lymphoid follicles
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26
Q

Gardia lambia

Cellular changes

A

Ventral sucking disc
Mechanical irritation
Malabsorption

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27
Q

Gardia lambia

Mild infection

A

Moderate and protracted diarrhea

6 weeks spontaneous recovery

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28
Q

Gardia lambia

Acute infection

A
Cramping and diarrhea
Exessive flatus ( rotten egg)

Bloating, nausea, anorexia more reported than diarrhea

29
Q

Gardia lambia

Chronic infection

A

Steatorrhea
Cholecystitis
Less diarrhea because pt is already dehydrated

30
Q

Gardia lambia

Severe infection

A

Malabsorption in the gut

Very weak

31
Q

Gardia lambia diagnosis

Watery stool

A

Not accurate

32
Q

Gardia lambia diagnosis

Semi formed stool

A

Best specimen

33
Q

Gardia lambia diagnosis

Stool exam

A

Demonstrate trophozoites or cyst

34
Q

Gardia lambia diagnosis

Direct fecal smear

A

Trophozoites seen as having a falling leaf-like motility

35
Q

Gardia lambia diagnosis

Invasive procedure

A

Duodenojejunal aspiration biopsy

36
Q

Gardia lambia diagnosis

May demonstrate trophozoite
An expensive test

A

Entero test

37
Q

Gardia lambia diagnosis

Enzyme linked immunosorbent assay using giardia antigen in the stool is a more sensitive method for indentifying giardia

A

ELISA

38
Q

Gardia lambia treatment

Metronidazole

A

500 mg TID for 5-10 days

39
Q

Gardia lambia treatment
Metronidazole
Pedriatic dose

A

15 mg/kg/day in 3 divided dosed

90% cure rate

40
Q

Gardia lambia treatment
Metronidazole
Side effect

A

Metallic taste

41
Q

Gardia lambia treatment

Tinidazole

A

2 g single dose for adults;

50 mg/kg in children

42
Q

Gardia lambia treatment

Furazolidine

A

100 mg QID for 7-10 days

43
Q

Gardia lambia treatment

Furazolidine

Pedriatic dose

A

6 mg/kg/day in 4 diided doses

44
Q

Gardia lambia prevention

A

Proper and sanitary disposal of excrete to prevent contamination of watery supplt and food

Avoidance of night soil as fertilizers, flies and infected food handlers

45
Q

Trichomonas vaginalis

A

STD

46
Q

Trichomonas vaginalis

Habitat

A

Urogenital tract

Vagina, urethra, prostate, epididymis

47
Q

Trichomonas vaginalis

Cyst

A

No cyst form

48
Q

Trichomonas vaginalis

Shape

A

7-23um

Pyriform shape

49
Q

Trichomonas vaginalis

Flagella

A

4 anterior flagella - simple stalk

5th flagella - undulating membrane, extends about 1/2 of original lenght

50
Q

Trichomonas vaginalis

Nucleus

A

Median axostyle

Sinke nucleus

51
Q

Trichomonas vaginalis

Multiply by

A

Bunary fission

52
Q

Trichomonas vaginalis

Transmission

A

Ping pong infection

53
Q

Trichomonas vaginalis

Diagnostic

A

Cystostome

Siderophil granules

54
Q

Trichomonas vaginalis

Aka

A

Jerky tumbling motility

55
Q

Trichomonas vaginalis

Trophozoite cant’t live without close association with

A

Vagina
Urethral
Prostatic tissue

56
Q

Trichomonas vaginalis

Trophozoite infect the surface but do not appear to invade the

A

Mucosa

57
Q

Trichomonas vaginalis

4-28 days after introduction of the trophozhoite into the vagina

A

Proliferation of flagella
Degenaration of vaginal epithelium
Leukocytic inflammation of tissue

58
Q

Trichomonas vaginalis

Acute infection

A

Greenish to yellowish secretion
Intense itchiness
Burning sensation

59
Q

Trichomonas vaginalis

Chronic stage

A

Loses purulent appearance due to decrease tirchomonads and leukocytes

Increase epithelial cells

Mixed bacterial flora

60
Q

Trichomonas vaginalis

Common symptoms

A

Vaginal discharge
Vulvitis
Dysuria
Postpartum endometritis

61
Q

Trichomonas vaginalis

Complication include secondary bacterial infection of the

A

Urogenital tract in male

62
Q

Trichomonas vaginalis

On speculumexamination, there are punctuate hemorrhages of the cervix

A

Strawberry cervix

63
Q

Trichomonas vaginalis diagnosis

A

Collectiin of discharge

64
Q

Trichomonas vaginalis diagnosis

From discharges

A

Saline wet mounts

65
Q

Trichomonas vaginalis diagnosis

In males

A

Prostatic secretions and urine

66
Q

Trichomonas vaginalis diagnosis

Culture using

A

Diamond ( modfied medium )

Feinberg and whittington culture medium

67
Q

Trichomonas vaginalis treatment

A

Metronidazole- 500 mg TID for 7 days (90-98% cure rate)

Tinidazole-2 mg single dose

68
Q

Trichomonas vaginalis

In RP, prevalence rate is

A

14-8% among sexual workers

69
Q

Tenax
Hominis
Vaginalis

A

Oral cavity
Large intestine
Uro- genital tract