block 6 lecture 2 consciousness and brain acivity Flashcards

1
Q

what is the medical definition of consciousness?

A

awar and responsive to surroundings

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2
Q

what happens in locked in syndrome?

A

Patient has awareness, sleep-wake cycles, and meaningful behaviour
but is isolated due to facial and body paralysis.

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3
Q

what happens in a minimally conscious state?

A

Patient has intermittent periods of awareness and wakefulness and displays some meaningful behaviour.

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4
Q

what happens in persistent vegetative state?

A

Patient has sleep-wake cycles, but lacks awareness; only displays reflexive and non-purposeful behaviour.

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5
Q

what happens in chronic coma?

A

Patient lacks awareness and sleep-wake cycles; only displays reflexive behaviour.

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6
Q

what happens in brain death?

A

Patient lacks awareness, sleep-wake cycles, and brain-mediated reflexive behaviour.

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7
Q

what are the most common causes of loss of consciousness?

A

Stroke (Haemorrhage/Thrombosis/Embolus), Cardiovascular, Diabetes, Drug induced (alcohol/other poison/overdose), Epilepsy, Head injury, Raised intracranial pressure (tumour/abscess), Dementia, Uraemia, Liver diseas

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8
Q

what is the glasgow coma scale based on?

A

eye response
verbal response
motor response

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9
Q

what is brain stem death?

A

irreversible loss of consciousness, ventilation and brain stem function

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10
Q

tests for brain stem death? 6

A
Pupil response 
Corneal reflex
Vestibulo-ocular reflex (VOR) 
Cranial nerve motor response
Cough/gag reflex
Respiratory effort
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11
Q

what happens in pupil response?

A

light shone in eye

pupil should constrict

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12
Q

what happens in corneal reflex?

A

cotton wool stoked on eye

lots of pain receptors, should blink

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13
Q

what happens in vestibulo-ocular response?

A

ice water put in ears

eyes should flicker

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14
Q

what is the brain stem area responsible for consciousness?

A

reticular activating system

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15
Q

what is the RAS?

A

collection of nuclei in the midbrain

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16
Q

why is it called the diffuse reticular system?

A

projects to all areas of the brain

17
Q

what are the 4 principle nuclei?

A

locus coeruleus
raphe nuclei
ventral tegmntum
cholinergic nuclei

18
Q

where is the locus coeruleus located?

A

pons

19
Q

what is the neurotransmitter in locus coeruleus?

A

noradrenaline

20
Q

when is the locus coeruleus active?

A

during arousal

21
Q

where is the raphe nuclei located?

A

mid brain

22
Q

what is the neurotransmitter in raphe nuclei?

A

serotonin

23
Q

when is the raphe nuclei active?

A

waking state

24
Q

what is the function of the raphe nuclei?

A

pain inhibition, cardiac rhythm

25
Q

what are the disorders of the raphe nuclei?

A

Depression, OCD

26
Q

what are the disorders of the locus coeruleus?

A

anxiety, panic, PTSD

27
Q

where is the ventral tegmentum?

A

midbrain

28
Q

what is the neurotransmitter in ventral tegmentum?

A

dopamine

29
Q

what is the ventral tegmentum involved in?

A

Involved in reward circuitry of the brain - reinforces pleasurable sensations, motivation, intense emotions