Block 3 Lecture 2 -- Tumor Immunology Flashcards
What is tumor-specific antigen (TSA)?
mutation of a normal protein
What is tumor-associated antigen (TAA)?
1) reactivation of embryonic genes
or 2) overexpression of self
What are the phases of the immune response to cancer?
1) priming phase
2) effector phase
What are the 2 macrophage populations?
1) anti-tumor (M1)
2) pro-tumor (M2)
How are anti-tumor macrophages induced?
LPS, IFN-gamma
How are pro-tumor macrophages induced?
hypoxia
How are tumor cells destroyed by the immune system?
1) Ab-mediated complement lysis
2) direct NK killing
3) ADCC
4) non-specific macrophage toxicity
5) tumor-specific CTL response
What are the components of ADCC?
perforin, granzyme, degranulation
What do anti-tumor macrophages produce?
1) cytokines/chemokines
2) ROS/RNS
3) MMPs
4) tumor lysis
What do pro-tumor macrophages produce?
1) cytokines/chemokines
2) ROS/RNS
3) MMPs
4) tissue factor
5) angiogenic cytokines/enzymes
What are the 3 phases of immunoediting?
1) elimination
2) equilibrium
3) escape
What percent of tumors do infectious agents cause?
15%
What infectious agents cause cancer?
HPV, HBV, H. pylori
What is the vaccine to HPV?
Gardasil
What cytokines/proteins are involved in the elimination phase of immunoediting?
anti-tumor
- perforin, TRAIL, TNFa, FasL
- IL-1, IL-12
- IFN a,b,g
