Block 1 Lecture 3 -- Cells of the Immune System Flashcards
What is present in the granules of neutrophils?
specific granules = lysozyme+collagenase+elastase; azurophilic granules = defensins+cathelicidins
What is present in the granules of basophils?
heparin + serotonin + histamine
What is present in the granules of mast cells?
histamine, heparin
What is present in the granules of eosinophils?
major basic protein (ABP) + cationic proteins
What are macrophages present in the peritoneum called?
resident
What are macrophages present in the lung called?
alveolar
What are macrophages present in the kidney called?
intraglomerular mesangium
What are macrophages present in the lymph nodes or spleen called?
sinusoidal
What type of B cells are B1 cells?
innate
What type of B cells are B2 cells?
memory
What are the granulocytes?
neutrophils + eosinophils + basophils + mast cells
What cells are phagocytes and APCs?
granulocytes + monocytes/macrophages/DCs
What cells are polymorphonuclear cells?
granulocytes
What cells are mononucelar cells?
lymphoids + monocytes/macrophages
What are CD markers?
binding patterns of Abs often associated with stages of differentiation
What are the types of Th cells?
Th1 + Th2 + Th17 + Th-follicular
How are Th1 cells ID’d?
CD4+ IFN-gamma
How are Th2 cells ID’d?
CD4+ IL-4
How are Th17 cells ID’d?
CD4+ IL-17
How are cytotoxic T’s ID’d?
CD8+
How are gamma-delta T cells ID’d?
CD4-CD8-; gamma-delta T cell receptor
Function of Th1 cells
cell-mediated immunity
Function of Th2 cells
humoral immunity
Function of Th17 cells
auto-immunity
Function of Th follicular?
B cell development
How are T lymphocytes ID’d?
CD3+
Fx of neutrophils
phagocytosis; earliest and most robust responder; activate bactericidal mechanisms
Fx of basophils
promote allergic response and augment anti-parisitic immunity thru presence in the blood
Fx of mast cell
work as tissue-resident basophils for granule release
Fx of eosinophils
kill Ab-coated parasites
Fx of professional phagocytes/macrophages:
phagocytosis and APC; activation of bactericial mechanisms; wound repair
Fx of APCs/DCs:
process and present Ag after migration to lymphocytes; T-cell activation
What are the APCs:
major = DC; minor = macrophage, B
Fx of NK cells
early recognition and destruction of viral infections and tumors; can kill via direct cytotoxicity after opsonization
How are NK cells stimulated and what happens after?
stimulated by lipids; then produce IFN-gamma for Th1 response
