Block 1 - Tissues Flashcards

1
Q

What are the four basic types of tissues and explain them?

A

Epithelial – covering and lining; glands Connective – connect, support, filling spaces Muscle – generate forces that provide for movement Nervous – cell-to-cell communication

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2
Q

________ _________ connect adjacent cells mechanically at the cell membranes or through cytoskeletal elements within and between cells.

A

intracellular junctions

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3
Q

_________ __________ are found where a leakproof seal is needed between cells. They keep materials from leaking out of organs like the stomach and bladder.

A

tight junctions

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4
Q

_________ __________ make an adhesion belt (like the belt on your pants) that Keeps tissues from separating as they stretch and contract. _________ (transmembrane proteins) attach to the plaque, partially cross the intercellular space, and connect to the same type of transmembrane protein from an adjacent cells Plaque attaches to microfilaments

A

Adherens junction cadherins

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5
Q

Desmosomes and adherens junctions are dissimilar because the plaque does not attach to ________, but rather attaches to ________ filaments

A

microfilaments; intermediate

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6
Q

Define a hemidesmosome.

A

“half desmosome”

Transmembrane glycoproteins called integrins replace the cadherins of desmosomes, and attach to the basement membrane Anchors an epithelial cell to the basement membrane.

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7
Q

In hemidesmosomes, the transmembrane glycoproteins called _______ replace the ________ of desmosomes

A

integrins

cadherins

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8
Q

All epithelia have a free ______ surface and an attached basal surface.

A

apical (free) surface

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9
Q

Moving external to internal, the epithelium has these layers:

epithelium –> ______ _______, made up of thes two lamina: ________ lamina, _______ lamina –> connective tissue where nerves and blood vessels are located.

A

basement membrane; basal lamina and reticular lamina

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10
Q

What are the functions of the epithelial cells?

A

Protection

Filtration

Secretion

Absorption

Excretion

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11
Q

Identify each layer arrangement and cell shape.

A

simple, psuedostratified, stratified

squamous, cuboidal, columnar

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12
Q

Simple squamous epithelium is composed of the single layer of flat cells found in:

A

In the air sacs of lungs

In the lining of blood

vessels, the heart, and lymphatic vessels

In all capillaries, including those of the kidney

As the major part of a

serous membrane

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13
Q

– Simple ________ makes up epithelial membranes and lines the blood vessels.

– ________ is common in the digestive tract.

–__________ ________ ________ is characteristic of the upper respiratory tract.

– __________ epithelium is found in the bladder.

– _________ epithelium lines ducts and sweat glands.

A

–Simple squamous makes up epithelial membranes and lines the blood vessels.

Columnar is common in the digestive tract.

–Pseudostratified ciliated

columnar is characteristic

of the upper respiratory tract.

–Transitional is found in

the bladder.

–Cuboidal lines ducts and

sweat glands.

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14
Q

Define Goblet cells.

A

Goblet cells are simple columnar cells that have differentiated to acquire the ability to secrete mucous

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15
Q

Fill in the blank.

A
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16
Q

Pseudostratified Columnar Epithelium has ciliated tissues that have cells that secrete mucous. What is the name of those cells?

A

Goblet cells

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17
Q

Keratinized and Non-keratinized are features of what type of tissue?

A

stratified squamous epithelium

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18
Q

What type of tissue is on top and bottom?

A

Top: nonkeratinized (outer layer still has nucleus) stratified squamous epithelium

Bottom: keratinized (outer layer loses nucleus) stratified squamous epithelium

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19
Q

What type of epithelium has an apical surface that is made up of two or more layers of cube-shaped cells?

A

stratified cuboidal epithelium

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20
Q

The cells of this epithelium can change shape depending on the state of the stretch in the tissue. What type of tissue is this?

A

transitional epithelium

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21
Q

Fill in the blanks in the diagram.

A
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22
Q

– Simple ________ makes up epithelial membranes and lines the blood vessels.

– ________ is common in the digestive tract.

–__________ ________ ________ is characteristic of the upper respiratory tract.

– __________ epithelium is found in the bladder.

– _________ epithelium lines ducts and sweat glands.

A

–Simple squamous makes up epithelial membranes and lines the blood vessels.

–Columnar is common in the digestive tract.

–Pseudostratified ciliated

columnar is characteristic

of the upper respiratory tract.

–Transitional is found in

the bladder.

–Cuboidal lines ducts and

sweat glands.

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23
Q

A specialized simple squamous epithelium that lines the entire circulatory system from the heart to the smallest capillary – it is extremely important in reducing turbulence of flow of blood.

Found in serous membranes such as the pericardium, pleura, and peritoneum.

A

Endothelium

Mesothelium

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24
Q

Single cell or group of cells that secrete substances into a duct, onto a surface or into the blood.

What do these screte into?

What two types are there?

A

Gland

ducts, surface, blood

exocrine / endocrine

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25
Explain exocrine. Explain endocrine.
**Exocrine** –Secrete to surface or lumen –Typically are multicellular, and have ducts (the only important unicellular exocrine gland in humans is the goblet cell) –Sweat, oil, mucus, enzymes **Endocrine** –Secrete to extracellular space –Ductless, having lost ducts during development –Diffuse to blood stream –Hormones
26
The criteria for categorizing multicellular glands according to function is based on the manner in which the gland secretes its product from inside the cell to the outside environment. What three types are there?
–Merocrine –Apocrine –Holocrine
27
In terms of exocrine glands, this gland has a secretion that is the most common manner of secretion. The gland releases its product by exocytosis and no part of the gland is lost or damaged
merocrine
28
This type of exorcine gland "bud” their secretions off through the plasma membrane, producing membrane-bound vesicles in the lumen of the gland. –The end of the cell breaks off by “decapitation”, leaving a milky, viscous odorless fluid. –This type of sweat only develops a strong odor when it comes into contact with bacteria on the skin surface.
Apocrine gland
29
These type of exocrine gland secretions are produced by rupture of the plasma membrane, releasing the entire cellular contents into the lumen and killing the cell (cells are replaced by rapid division of stem cells.) The sebaceous gland is an example because its secretion (sebum) is released with remnants ofdead cells.
holocrine
30
**What is the basic type of tissue that has these functions?** Binds, supports, and strengthens other body tissues (bone, cartilage) Protects and insulates internal organs Compartmentalizes (fascia) Transports (blood) Stores energy (adipose tissue) Main source of immune responses
connective tissue
31
Connective tissue is composed of what?
cells extracellular matrix made up of: protein fibers / ground substance
32
**True or False**: The epithelium has many cells, few ground substance, few fibers and lots of arteries. **True or False**: The connective tissue has few cells, lots of ground substance, lots of fibers and lots of arteries.
False; no arteries True
33
Connective tissue cells arise from \_\_\_\_\_\_\_\_\_\_, which is an embryonic connective tissue.
mesenchyme
34
What suffix is given for "immature cells" and "mature cells"?
- blast - cyte
35
What are the differences between blast cells and mature cells in terms of cell division?
Blasts are mitotically competent and secrete the matrix that is characteristic of the tissue while mature cells ahve reduced capacity for cell division and matrix formation. Typically mature cells are generally involved with maintaining the matrix.
36
Fill in the blanks.
37
Most common cell of connective tissue in general Large, flat cells with branching processes *Migrate throughout connective tissue* to secrete and maintain the matrix (matrix = fibers (collagen, reticular fibers, elastic fibers) and ground substance (GAGs and glycoproteins))
Fibroblast
38
Develop from monocytes Irregularly shaped, having filopodia (short branching projections that contain actin) whereby they move Engage in phagocytosis
macrophage
39
What type of macrophage is found: fixed in the liver fixed in primarily skin and lymph nodes wandering in bone wandering in blood wandering in the central nervous system
Kupffer cells Langerhanns cells Osteoclasts Alveolar macrophage AKA dust cell monocyte Microglia
40
What type of cell is abundant alongside blood vessels of connective tissues? It can be phagocytic
mast cells
41
What are the granules stored in mast cells-referred to as "primary mediators"?
heparin histamines proteases aryl sulfatases ECF / NCF
42
What "granule" dilates small blood vessels as part of the inflammatory response? What does ECF and NCF stand for?
histamines Eosinophil chemotactic factor Neutrophil chemotactic facter
43
What secondary mediators can be synthesized "on the spot" by mast cells?
leukotrienes thromboxanes prostaglandins cytokines
44
**What type of cell?** Large; spherical Signet ring-shaped Synthesizes and stores lipid Vacuole of fat Filler
Adipose cell
45
What are the types of leukocytes?
–Lymphocytes –Monocytes –Neutrophils –Eosinophils –Basophils
46
In short, what is the composition and function of the connective tissue?
**Composition**: protein fibers ground substance (may be fluid, semifluid, gelatinous, or calcified) **Function**: occupies space between cells and fibers provides structural support for connective tissue
47
What are the polysaccharides in the ground substance?
hyaluronic acid chrondroitin sulfate dermatan sulfate keratan sulfate \* associated with proteins called proteoglycans
48
**True or False**: Glycosaminoglycans are highly negatively charged and very hydrophillic.
49
What are the protein/carbohydrate substance that forms a core protein of a complex resembling a test-tube brush, with GAGs projecting from the core?
Proteoglycans
50
# Define each with a term: Viscous, slippery substance that binds cells together, lubricates joints, and helps maintain the shape of the eyeballs (vitreous body) Provides support and adhesiveness in cartilage, bone, skin, and blood vessels Is found in skin, tendons, blood vessels and heart valves In bone, cartilage and the cornea of the eye Is the main adhesion protein of connective tissue
Hyaluronic acid Chondroitin sulfate Dermatan sulfate Keratan sulfate Fibronectin
51
What are the three connective tissue fibers?
Collagen fibers Elastic fibers Reticular fibers
52
Describe collagen fibers.
Abundant throughout the body Inelastic Flexible Tensile strength greater than steel Arranged in parallel bundles
53
Describe elastic fibers.
Small, branching fibers Form network within tissues **Constitution**: –Elastin (protein) –Fibrillin (glycoprotein) –Fibrillin surrounds the elastin **Locations:** –Skin –Walls of blood vessels –Lung tissue
54
Describe reticular fibers.
Fine bundles of collagen coated with glycoprotein Fibers are much thinner than collagen fibers, and form a branching network Provide support and strength (as does collagen) **Locations** –Blood vessels tissues: areolar connective, adipose, smooth muscle –Reticular connective tissue, forming the stroma AKA reticulum (supporting framework) of soft organs such as spleen and lymph nodes –Component of basement membrane
55
Within connective tissue classification, what are the sub-types: embryonic connective tissue mature connective tissue
**embryonic connective tissue** mesenchyme mucous connective tissue **mature connective tissue** _Loose_: areolar, adipose, reticular _Dense_: dense regular, dense irregular, elastic CT _Cartilage_: hyaline, fibrocartilage, elastic carilage Bone _Liquid_: blood tissue, lymph
56
Composed of irregularly shaped cells, a semifluid ground substance, and reticular fibers **Pleuripotent cells**--all other connective tissues eventually arise from mesenchyme Located along developing bones of the embryo and under the skin
Mesenchyme
57
Variant of mesenchyme containing widely scattered fibroblasts, more viscous jelly-like ground substance, plus collagen fibers Found in umbilical cord of fetus High turgor resists compression
mucous connective tissue (aka Wharton's Jelly)
58
What are the locations and types of LOOSE CONNECTIVE TISSUES?
**locations**: Deep to skin deep to mesothelial lining of the internal body cavities around blood vessels surrounds glandular parenchyma **types**: areolar CT adipose tissue reticular CT
59
One of the most widely distributed connective tissues in the body Contains the “usual” types of connective tissue cells: fibroblasts, macrophages, plasma cells, adipocytes, white blood cells All three types of fibers are arranged randomly throughout the tissue In conjunction with adipose tissue, it forms the subcutaneous layer, attaching the skin to underlying tissues
Areolar CT
60
A loose connective tissue, well vascularized Generally found wherever areolar connective tissue is located Adipocytes are derived from fibroblasts, and are specialized for storage of triglycerides (fats) Good insulator, and reduces heat loss Major energy reserve, as well as protecting various organs
Adipose Tissue
61
Consists of fine interlacing reticular fibers and reticular cells Forms the stroma (supporting framework) of liver, spleen, lymph nodes In the spleen, reticular fibers remove worn out red blood cells In the lymph nodes, reticular fibers filter lymph and remove bacteria
Reticular CT
62
What type of connective tissue is found in these locations: –Lymph nodes –Spleen –Liver sinusoids –Bone marrow –Smooth muscle –Some fat tissue –Islets of Langerhans
reticular CT
63
# Define this connective tissue: General locations in the body –Parts subject to tensive forces –Parts requiring flexibility and strength Overall feature: more fibers than cells
dense connective tissue
64
What are the three types of dense connective tissue:
dense regulative connective tissue (DRCT) dense irregular connective tissue (DICT) elastic connective tissue
65
Bundles of collagen fibers regularly arranged in parallel patterns, providing tensile strength along the axis of the fibers Fibroblasts produce fibers and ground substance, and are in rows between the fibers Examples: tendons, aponeuroses, and most ligaments
Dense Regular CT
66
Collagen fibers are abundant, and not arranged in symmetrical or parallel fashion Generally found in parts of the body where pulling forces are exerted in various directions Locations: * Dermis of skin * Periosteum * Pericardium * Sheath of nerves * Heart valves * Kidney * Perichondrium * Lymph nodes
Dense irregular tissue
67
Consists predominantly of branching elastic fibers Fibroblasts present in spaces between the fibers Unstained tissue has a yellowish color due to the high numbers of elastic fibers Has property of elasticity
Elastic CT
68
What are the major types of membranes?
mucous, serous, cutaneous
69
What is unique about synovial membranes that line the joints?
Contain connective tissue but no epithelium
70
What type of membrane consists of a lining of epithelium and an underlying layer of connective tissue called the lamina propria?
mucous membrane
71
What are the two serous membrane types?
parietal visceral
72
\_\_\_\_\_\_\_\_\_\_ membranes are composed of a ___________ layer and an underlying layer of areolar and adipose connective tissue, but there is *no epithelial layer*.
synovial; synoviocyte
73
Diseases in which the body produces antibodies that fail to distinguish self from non-self, and attack the body’s own tissues (connective tissues).
autoimmune disorder
74
A connective tissue disorder transmitted as an autosomal dominant trait. The fibrillin gene is defective, resulting in abnormal development of elastic fibers. Structures most affected are the periosteum, suspensory ligaments of the eye, and walls of large arteries. People with Marfan syndrome tend to be tall and have disproportionately long arms, legs, fingers, and toes.
marfan syndrome
75
The replacement of a diseased or injured tissue or organ with cells or tissues from an animal. Porcine (pig) and bovine (cattle) heart valves are used for some heart valve replacement surgeries.
xenotransplantation