Block 1 Fitz Drugs Flashcards

0
Q

What is Etoposide?

Mechanism, cell cycle, renal, IV/oral, support

A

Topo II inhibitor
Late S/ early G2
IV/oral

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1
Q

What is ifosfamide?

Mechanism, cell cycle, renal, IV/oral, support

A

Cross link DNA
S phase
IV
Renal toxicity from metabolite: chloroacetaldehyde

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2
Q

What is Busulfan?

Mechanism, cell cycle, renal, IV/oral, support

A

G-A cross link. Alkylating agent
Non specific
IV/oral

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3
Q

What is Fludarabine?

Mechanism, cell cycle, renal, IV/oral, support

A

Inhibits DNA polymerase, it’s a purine
S phase
IV
Granulocyte colony stim factor

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4
Q

What is Ara-C (cytarabine)?

Mechanism, cell cycle, renal, IV/oral, support

A

Inhibits DNA pol. And repair
S phase
All but oral
Granulocyte stuff

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5
Q

What is cysplatin?

Mechanism, cell cycle, renal, IV/oral, support

A
Cross links DNA G. Uses platinum.
Nonspecific
IV/oral
Nephrotoxic
Hyper hydration
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6
Q

What is methotrexate?

Mechanism, cell cycle, renal, IV/oral, support

A
Folate antagonist 
S phase
IV 
Leucovorin helps
Decrease pH and GFR
Hydration and alkylation
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7
Q

What is Doxorubicin?

Mechanism, cell cycle, renal, IV/oral, support

A

Intercalating agent, inhibiting topo II
Non specific
Immunosuppressive

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8
Q

What is 5-fluorouracil?

Mechanism, cell cycle, renal, IV/oral, support

A

Pyrimidine analog,thy idyl ate synthesis

S phase

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9
Q

What is Paclitaxel?

Mechanism, cell cycle, renal, IV/oral, support

A

Promotes microtubule stabilization
M phase
No bone marrow suppression

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10
Q

What is cyclophosphamide?

Mechanism, cell cycle, renal, IV/oral, support

A
Alkylating agent
Non specific
Converted to mustard
Bone marrow suppression
Gives Mensa to help with suppression
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11
Q

What is Vincristine?

Mechanism, cell cycle, renal, IV/oral, support

A

Microtubule binder, interferes with spindle formation

Metaphase arrest

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12
Q

What is Carmustine? (BCNU)

Mechanism, cell cycle, renal, IV/oral, support

A

Alkylating DNA and RNA
Non specific
Fungal infection possible with wafer

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13
Q

What is temozolomide?

Mechanism, cell cycle, renal, IV/oral, support

A

Crosses BBB, alkylation agent
Non specific
Secondary malignancies possible

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