Block 1 Fitz Drugs Flashcards
What is Etoposide?
Mechanism, cell cycle, renal, IV/oral, support
Topo II inhibitor
Late S/ early G2
IV/oral
What is ifosfamide?
Mechanism, cell cycle, renal, IV/oral, support
Cross link DNA
S phase
IV
Renal toxicity from metabolite: chloroacetaldehyde
What is Busulfan?
Mechanism, cell cycle, renal, IV/oral, support
G-A cross link. Alkylating agent
Non specific
IV/oral
What is Fludarabine?
Mechanism, cell cycle, renal, IV/oral, support
Inhibits DNA polymerase, it’s a purine
S phase
IV
Granulocyte colony stim factor
What is Ara-C (cytarabine)?
Mechanism, cell cycle, renal, IV/oral, support
Inhibits DNA pol. And repair
S phase
All but oral
Granulocyte stuff
What is cysplatin?
Mechanism, cell cycle, renal, IV/oral, support
Cross links DNA G. Uses platinum. Nonspecific IV/oral Nephrotoxic Hyper hydration
What is methotrexate?
Mechanism, cell cycle, renal, IV/oral, support
Folate antagonist S phase IV Leucovorin helps Decrease pH and GFR Hydration and alkylation
What is Doxorubicin?
Mechanism, cell cycle, renal, IV/oral, support
Intercalating agent, inhibiting topo II
Non specific
Immunosuppressive
What is 5-fluorouracil?
Mechanism, cell cycle, renal, IV/oral, support
Pyrimidine analog,thy idyl ate synthesis
S phase
What is Paclitaxel?
Mechanism, cell cycle, renal, IV/oral, support
Promotes microtubule stabilization
M phase
No bone marrow suppression
What is cyclophosphamide?
Mechanism, cell cycle, renal, IV/oral, support
Alkylating agent Non specific Converted to mustard Bone marrow suppression Gives Mensa to help with suppression
What is Vincristine?
Mechanism, cell cycle, renal, IV/oral, support
Microtubule binder, interferes with spindle formation
Metaphase arrest
What is Carmustine? (BCNU)
Mechanism, cell cycle, renal, IV/oral, support
Alkylating DNA and RNA
Non specific
Fungal infection possible with wafer
What is temozolomide?
Mechanism, cell cycle, renal, IV/oral, support
Crosses BBB, alkylation agent
Non specific
Secondary malignancies possible
