Bleeding disorders

Question 1

VW inheritance

Answer 1

Autosomal dominant

Usually behaves like platelet disorder / nosebleeds and menorrhagia

Question 2

Ix results in von willebrands

Answer 2

Prolonged bleeding time
APTT may be prolonged
Factor VIII levels may be moderately reduced

Question 3

DIC blood picture ?

Answer 3

A typical blood picture includes:
↓ platelets
↓ fibrinogen
↑ PT & APTT
↑ fibrinogen degradation products
schistocytes due to microangiopathic haemolytic anaemia

Question 4

Haemophillia A

Answer 4

Factor VIII

Question 5

Haemophillia B

Answer 5

Factor IX (Christmas disease)

Question 6

Haemophillia blood results?

Answer 6

prolonged APTT
bleeding time, thrombin time, prothrombin time normal

Question 7

What is the most common inherited thrombophilia?

Answer 7

Factor V Leiden

Activated protein C resistance

Question 8

G6PD features

Answer 8

neonatal jaundice is often seen
intravascular haemolysis
gallstones are common
splenomegaly may be present
Heinz bodies on blood films. Bite and blister cells may also be seen

Question 9

Rx of thrombocytosis?

Answer 9

Hydroxycarbamide

Question 10

Bloods in TLS?

Answer 10

High potassium, High phosphate, low calcium

Question 11

Clinical tumour lysis syndrome?

Answer 11

Clinical tumor lysis syndrome: laboratory tumour lysis syndrome plus one or more of the following:
increased serum creatinine (1.5 times upper limit of normal)
cardiac arrhythmia or sudden death
seizure