Biosignaling (German) - week 5 Flashcards
List in order smallest to greatest distance traveled in the types of signaling
- Autocrine (signals itself)
- Synaptic
- Paracrine (enviorment)
- Endocrine (meters)
List the four components of signal transduction
- signal
- receptor
- transduction pathways
- targets
Which type of signaling sends a signal to communicate with its enviorment
Paracrine
What are the 3 categories of Signals?
- Soluble
- Proteins
- Lipids
- Carbs - Linked (integrin)
- Physical
- Mechanical, light & temperature
List the 7 types of receptors
- G - protein coupled
- Receptor tyrosine kinase
- receptor guanylyl cyclase
- ligand gated ion channels
- adhesion
- nuclear
- cytokine
What are 2 ways membranes allow signaling complex formation?
Protein scaffolds & signaling endosomes
Endosome - signal is constantly being activated by ligand BC volume is much smaller than compared to cell
In what type of lipid raft does a clathrin mediated type form into?
It does not form in a lipid raft domain! Trick question
What type of lipid raft does phagocytosis and macropinocytosis occur?
Mixed membrane domain
2 types of lipid rafts?
Caveolar
Planar
Name a common primary effector
Adenylyl cyclase
enzyme, primary effectors are usually enzymes
What is a common signal transducer?
G protein
What does Epinephrine signaling effect?
Vascular tone -
- High = smooth muscle relaxation
Low = Smooth muscle contraction
Which type of signal pathway does epinephrine & Norepinephrine use?
G - protein signal transduction pathway
+
PLC signaling
Which type of signaling regulates cellular metabolism and division?
Insulin
-RTK, MAPK, & PI3K signaling
Transoports glucose into cells, alters blood sugar & enables aerobic respiration
What does phsopholipase C do?
Breaks down lipids
