Biomedical research & animal welfare Flashcards
1
Q
Ovine model of tachycardia-induced heart failure for High Rate Pacing
A
• sheep • chronic & stable for multiple interventions • translatable • mitral regurgitation & atrial fibrillation
2
Q
What analysis tools are there for tachycardia-induced heart failure
A
• pressure and derivatives • Volcano Flow and Pressure wire • clinical pathology
3
Q
What are the three ways to improve in researching disease and tecniques
A
Replace, Reduce, Refine
4
Q
What does replace mean
A
• Replacement of animals with other methods.
5
Q
What does Reduce mean
A
- Reduction in numbers of animals used.
* Scientifically & statistically valid • No repetition • Do not create a cumulative experimental burden
6
Q
What does Refine mean
A
- Refinement of techniques to reduce the impact on animals.
* Suitability • Techniques • Avoid/minimise
7
Q
What variability are there for animal welfare research
A
- Stress • Infection • Pain – Indicators of pain linked to natural response
- Sheep
