Biological Explanations Flashcards
genetic
how do researchers understand the possibility of the genetic basis
family studies, comparing concordance rates
genetic
there are multiple genes involves meaning SZ is ……
polygenic
genetic
what does aetiologically heterogeneous mean
different combination of factors, including genetic variation that lead to the condition
genetic
give a study that supports the role of genetics
riley and kendler
- lifetime risk of developing disorder is 1%
- risk is 10x higher if first degree relative has disorder
genetic
give the family study that supports the role of genetics
gottesman
- someone with relative with disorder has this possibility of developibng disorder
- aunt: 2%
- sibling: 9%
- identical twin: 48%
neural
whats the neurotransmitter associated with SZ
dopamine
neural
explain the original dopamine hypothesis
- excess dopamine in subcortical areas of the brain - hyperdopaminergia
- linked with positive symproms
neural
explain the updated dopamine hypothesis
- low dopamine in the brains cortex - hypodopaminergia
- linked to negative symptoms
- leads to subcortical hyperdopaminergia
- so both high and low levels of DA in different brain regions
neural
what is the mesocortical pathway
- hypodopaminergia
- outer layer of brain - low DA
- negative symptoms
neural
what is the mesolimbic pathway
- hyperdopaminergia
- inner layer of brain - high DA
- positive symptoms
neural
give a study that supports the role of drug use in SZ
di forti et al
- increases risk of developing disorder is associated with smoking high levels of THC in teenage years
neural
give a study that supports the role of trauma in SZ
- 67% of patients with psychotic conditions reported at least one childhood trauma
neural
giver study that supports the role of dopamine
tenn et al
- used amphetamines, which icrease DA, to induce SZ like symptoms in rats
- then reduced them using drugs
- supports the hypothesis
neural
