biological basis of addiction and schizophrenia Flashcards

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1
Q

how do drugs affect the mesolimbic pathway?

A
  • most drugs share the ability to increase dopamine release dopamine in the nucleus accumbens which is the terminal region for the mesolimbic pathway
  • by activating the pathway the drug increase motivation towards behaviours associated with taking the drug
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2
Q

treatments for schizophrenia

A
  • chlorpromazine (antagonist at dopamine receptors)
  • haloperidol (antagonist at dopamine receptors)
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3
Q

how is dopamine involved in schizophrenia?

A
  • typical antipsychotic drugs are dopamine antagonists but is only effective in 50% of patients
  • therefore dopamine systems are involved but only in POSITIVE SYMPTOMS
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3
Q

how is dopamine involved in schizophrenia?

A
  • typical antipsychotic drugs are dopamine antagonists but is only effective in 50% of patients
  • therefore dopamine systems are involved but only in POSITIVE SYMPTOMS
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4
Q

neurochemical basis of schizophrenia

A
  • several drugs cause symptoms similar to schizophrenia eg:
  • amphetamine (increase dopamine)
  • LSD (5HT agonist)
  • phencyclidine (glutamate agonist)
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