BioCog 2A neurotransmission Flashcards by Luca W

Q

soma

A

cell body

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Q

axodentric

A

axon + dendrite

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Q

axosomatic

A

axon + soma

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Q

microtubule

A

transport vesicles to presynaptic membrane

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Q

vesicles

A

contain neurotransmitter

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Q

exocytosis

A

outflow of neurotransmitters

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Q

kiss and run

A

immediately go back

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Q

merge and recycle

A

stay for little longer

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Q

bulkendocytosis

A

take part of the membrane with them

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Q

Na+

A

= sodium

postsynaptic membrane
EPSP

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Q

Ca2+

A

= calcium

presynaptic membrane
EPSP

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Q

Cl-

A

= chlorine

- IPSP

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Q

metabotropic receptors

A

open ion channels indirectly

- by G protein or 2nd messenger

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Q

G protein

A

released by NT
alpha unit breaks off
opens ion channel

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Q

2nd messenger

A

alpha unit of a G protein activates it

- then opens ion channel

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Q

AChE

A

splits ACh

- only example for enzym degredation

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Q

autoreceptors

A

metabotropic
either activate reuptake transporters
or reduce NT release

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Q

Ach

A

learning, motor

Q

monoamines

A

catecholomines
-> dopamine, norepinephrine, epinephrine
idolamines
-> serotonine

Q

dopamine

A

reward, motor

Q

norepinephrine

A

alertness
fight/flight
SNS

Q

epinephrine

A

flight/fight

- SNS

Q

serotonine

A

mood

Q

aminoacids

A

glutamate
gylcine
GABA

Q

glutamate

A

excitatory

- mptor

Q

gylcine

A

inhibitory
motor
only in spine

Q

GABA

A

inhibitory

- motor

Q

neuromodulators

A

wander through brain
dont cause potentials
hormones or nucleosides

Q

vasopressine

A

hormone

- aggression

Q

oxytocine

A

hormone

- bonding

Q

ligand

A

chemical that binds to receptors

Q

competitive binding

A

binds to neurotransmitter site

Q

non-competitice binding

A

binds to other side

Q

L-DOPA

A

dopamine prescursor

- > indirect agonist

Q

black widow venom

A

stimulates ACh release

- > indirect agonist

Q

nicotine

A

simulates postsynaptic ACh receptors

- > direct agonist

Q

indotoxon

A

blocks norepinephrine autoreceptors

- > indirect agonist

Q

cocaine

A

block dopamine reuptake

- > indirect agonist

Q

physotigmine

A

inactivates AChE

- > indirect agonist

Q

reserpine

A

prevents monoamine storage in vesicles

- > indirect antagonist

Q

botulinum toxin

A

inhibits ACh release

- > indirect antagonist

Q

curare

A

blocks postsynaptic receptors

- > direct antagonist

Q

PCPA

A

inhibits serotonine synthesis

- > indirect antagonist

Q

apomorphine

A

stimulates dopamine autoreceptors

- > indirect antagonist