BioChem - Na/K Pump Flashcards
The sodium potassium pump utilized what kind of transport?
Active transport
What powers the Na/K+ pump?
ATP
How much sodium is exchanged for potassium per process?
3 Na for 2 K+
What does this pump generate intracellularly?
Concentration gradients
Explain what happens to the pump when sodium binds:
Cytoplasmic sodium binds and ATP phosphorylates the pump causing a conformational change and the sodium is released
Explain what happens to the pump when Potassium binds:
When potassium binds, there is dephosphorylation, causing conformational change back to the original state, K+ gets released and the cycle repeats once sodium binds
What does insulin do to the sodium potassium pump?
Insulin phosphorylates Na/K+ pump, increasing pump activity, shifts K+ back into cells and decreases serum potassium
How does the pump establish a resting membrane potential?
Na+ pumped out, K+ pumped in, and potassium leaky channels cause K+ to leak out down gradient resulting in a (-) intracellular charge
Which gradient allows for cotransport/antiport of materials?
Sodium
What helps with the reabsorption of glucose from urine?
Na/Glucose costransport
What is the role of SGLT2 inhibitors?
They block Sodium glucose cotransport, ultimately decreasing glucose reabsorption
What is the exchange rate for sodium and calcium?
3 sodium in for 1 calcium out
When there’s a decrease in serum __________ it enters along the gradient and exchanges itself for calcium
Sodium
What electrolyte in cardiac myocytes controls inotropy?
Calcium
What is the overall effect of cardiac glycosides?
Causes a decreased exchange between sodium and calcium, causing an increase in calcium concentration in the heart effectively increasing inotropy
