BIOC Lipid Metabolism Flashcards
What is the exogenous pathway?
the process by which dietary lipids are absorbed from the gastrointestinal tract and transported through the body
What is the endogenous pathway?
the production, transport, and utilization of lipids synthesized within the body, primarily by the liver
EXO: Where do chylomicrons come from?
The intestine
EXO: What are chylomicrons metabolised by?
LPL
EXO: What is the co-factor that LPL requires?
ApoCII
EXO: What happens when LPL hydrolyzes chylomicrons?
LPL hydrolyses the fatty acids that are found in TAGs (which chylomicrons are loaded with)
EXO: What happens to fatty acids that have been hydrolysed by LPL?
Hydrolyzes the fatty acids from their glycerol backbone, and these fatty acids are taken up by tissues that require them
EXO: What particles remain after LPL has hydrolysed Chylomicrons?
Chylomicron remanants
EXO: What are chylomicron remnents?
Essentially chylomicrons that have lost most of their TAG core
EXO: How are chylomicron remnants taken up by the liver?
By the receptor LRP
ENDO: Where do VLDL particles come from?
The liver
ENDO: What are VLDL metabolised by?
LPL
ENDO: What co-factor does LPL need?
ApoCII
ENDO: What particles remain after LPL hydrolyses VLDL?
IDL particles
ENDO: What is another name for IDL?
VLDL remaments
