Bio Bases Flashcards

1
Q

Stages of brain dev

A

o Proliferation (2.5 weeks), migration (8 weeks), differentiation (cells become more distinct), myelination, synaptogenesis (postnatal)

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2
Q

Aphasias

A

o Wernickes-receptive or sensory aphasia (problems with comprehension, fluent speech but meaninginless)
o Broca- expressive or motor aphasia, intact comprehension but poor articulation
o Conduction- damage link between Wernickes and Broca- intact fluency and comp (paraphasia-misusing speech sounds)
o Global aphasia-damage to most of the cortex-impairment in most lang fx

Transcortical Motor Aphasia is a type of non-fluent aphasia. This means that speech is halting with a lot of starts and stops. People with TMA typically have good repetition skills, especially compared to spontaneous speech.

Patients with transcortical sensory aphasia (TSA) have fluent and paraphasic speech (global paraphasias predominate over phonemic) and a severe impairment in aural comprehension. Yet their repetition is intact (occasionally echolalic), setting them clearly apart from Wernicke’s aphasics.

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3
Q

seizures

A

generalised:
grand mal (tonic-clonic) (muscles contract then shake)
petite mal (loss of cs w/o shakes)

Partial:
simple (Jacksonian) (no loss of cs)
complex (some alteration in cs)

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4
Q

General adaptation syndrome (GAS)

A

describes the process your body goes through when you are exposed to any kind of stress, positive or negative. It has three stages: alarm, resistance, and exhaustion. If you do not resolve the stress that has triggered GAS, it can lead to physical and mental health problems.

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5
Q

catecholamines

A

dopamine, norepinephrine, epinephrine

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6
Q

hindbrain

A

medulla, cerebellum, pons

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7
Q

midbrain

A

substantia nigra, reticular formation (RAS), superior and inferior colliculi

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8
Q

forebrain

A

cerebral cortex (frontal, parietal, occipital, temporal)

subcortical structures: thalamus, hypothalamus, hippocampus, amygdala, basal ganglia (motor)

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9
Q

cones

A

color vision and fine detail

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10
Q

rods

A

low light, night vision, peripheral vision, black and white

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11
Q

weber’s law

A

the more intense a stimulus the greater the increase in stimulus intensity required for the increase to produce a Just Noticeable Effect

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12
Q

Fechner’s Law

A

extension of weber’s law

a mathematical formula relating subjective experience to changes in physical stimulus intensity: Specifically, the sensation experienced is proportional to the logarithm of the stimulus magnitude.

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13
Q

Steven’s Law

A

Stevens’ power law is an empirical relationship in psychophysics between an increased intensity or strength in a physical stimulus and the perceived magnitude increase in the sensation created by the stimulus.

as a stimulus gets stronger, we become increasingly less sensitive to the stimulus changes. Sometimes as the stimulus intensity increases, our sensitivity keeps roughly constant.

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14
Q

LTP

A

Long-term potentiation, or LTP, is a process by which synaptic connections between neurons become stronger with frequent activation. LTP is thought to be a way in which the brain changes in response to experience, and thus may be an mechanism underlying learning and memory.

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15
Q

Sleep Stages

A

BATD

beta- alert, fully awake

stage 1 alpha
stae 2 theta (sleep spindles and K-complexes)
stage 3 and 4 delta waves

REM looks like awake

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16
Q

agonist drugs

A

drugs that produce similar effects to a NT

direct-mimic NT
indirect- attach to another receptor cell and facilitate the action of the NT

Partial ag- produces effects similar or less than the NT

inverse ag- produce opposite effect of NT

17
Q

antagonist drug

A

reduce or block the effect of NT

direct-attach to receptor site to block NT
indirect-attach to other receptor site and interfere with the action of the nT

18
Q

conventional antipsychotics

A

haloperidol

block dopamine receptors

side effects- anticholinergic effects, extrapyramidal effects, neuroleptic malignant syndrome

19
Q

anticholinergic effects

A

dry mouth, urinary retention, blurred vision, constipation, tachycardia, delayed ejaculation

20
Q

extrapyramidal effects

A

Akathisia: Feeling restless like you can’t sit still. You may have the urge to tap your fingers, fidget, or jiggle your legs.
Dystonia: When your muscles contract involuntarily. It can be painful.
Parkinsonism: Symptoms are similar to Parkinson’s disease. You may have a tremor, difficulty finishing thoughts or speaking, and stiff facial muscles. ‌But while a loss of nerve cells causes Parkinson’s disease, the medication causes Parkinsonism.
Tardive dyskinesia: Facial movements happen involuntarily. You may make a sucking or chewing motion with your mouth, stick out your tongue, or blink your eyes a lot.

21
Q

neuroleptic malignant syndrome

A

a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction.

22
Q

atypical antipsychotics

A

clozepine

anticholinergic effects, lowered seizure potential, sedation, extrapyramidal (but less than conventionals), agranulocytosis, NMS

23
Q

tricyclics

A

imipramine, clomipramine

block reuptake of nore, sero and/or dop

lethal overdose, cv sx, anticholinergic, drowsiness, fatigue, weight gain, tremor

24
Q

SSRI

A

fluoxetine

safer in overdose and less cardiotoxic

gi distress, insomnia, sexual dyfx, headache, anxiety, anorexxia, tremor, urination

25
Q

MAOIs

A

inhibit monoamine oxidase

hypertensive crisis, (if mixed with barbiturates, amphetamines, antihistamines, alcohol and food with tyramine), antichol., insomnia, weight gain, headache, skin rash, edema, tremor

26
Q

mood stabilizers

A

lithium-gi distress, tremor, weight gain, toxicity, effects sodium levels

carbamazepine- agranulocytosis, anemia, anorexia, ataxia, rash