BICARBONATE

Question 1

2ND MOST ABUNDANT ANION IN THE ECF
Accounts for more than 80% of total CO2 with HCO3-
An alkaline agent (↑plasma pH ↑ HCO3-)

Answer 1

BICARBONATE

Question 2

T/F. Chloride Shift: Gets out of the cell once it is produced in exchange for chloride

Answer 2

True

Question 3

T/F. Major component of BICARBONATE- CARBONIC ACID BUFFER SYSTEM of the blood

Answer 3

True

Question 4

Major buffer system in maintaining the normal plasma pH

Answer 4

BICARBONATE- CARBONIC ACID BUFFER SYSTEM

Question 5

can buffer excess H+ by combining w excess acid to produce H2CO3

Answer 5

HCO3-

Question 6

T/F. HCO3- is reabsorbed abnormally in the kidneys

Answer 6

False, reabsorbed normally

Question 7

Percentage of Bicarbonate that reabsorbed in the PROXIMAL CONVOLUTED TUBULE

Answer 7

85%

Question 8

Percentage of Bicarbonate that reabsorbed in DISTAL CONVOLUTED TUBULE

Answer 8

15%

Question 9

CAUSE of Increased BICARBONATE

Answer 9

Metabolic Alkalosis

Question 10

CAUSES of Metabolic Alkalosis

Answer 10

Severe vomiting, Hypokalemia
Hypoventilation
Excessive alkali intake

Question 11

CAUSE of Decreased BICARBONATE

Answer 11

Metabolic Acidosis

Question 12

CAUSE of Metabolic Acidosis

Answer 12

Hyperventilation

Question 13

What are the tube and specimen needed for Specimen Collection of Bicarbonate?

Answer 13

Serum, Plasma (heparin)

Question 14

T/F. False ↓ if left uncapped

Answer 14

True

Question 15

False ↓ if left uncapped because CO2 can be released into atmospheric air and this could

Answer 15

decrease 6 mmol/L of bicarbonate per hour

Question 16

Uses pCO2 electrode for bicarbonate

Answer 16

ISE

Question 17

Reaction:
Phosphoenolpyruvate + HCO3 – PEP carboxylase → Oxaloacetate + H2PO4–
Oxaloacetate + NADH + H+ –MDH → Malate + NAD+

Answer 17

Enzyme method

Question 18

T/F. (INCREASED ABSORBANCE of the oxidized NAD+ at 340nm is measured)

Answer 18

False, (DECREASED ABSORBANCE of the oxidized NAD+ at 340nm is measured)