Bennett

Question 1

What is sarcoidosis

Answer 1

• Inflammatory process that PRODUCES GRANULOMAS, which may be in various organs
• symptoms of sarcoidosis stem from the CLUMPING OF GRANULOMAS, which affect its ability to function
• More common in African Americans

Question 2

What are the two phases of granulomas

Answer 2

• Active Phase = the granulomas form and grow in this phase, symtpoms develop and scar tissue can form
• INactive phase: inflammation subsides, the granulomas shrink or stay the same size. But the scares remain and cotninue to produce symtpoms

Question 3

describe the 5 stages of Sarcodosis

Answer 3

• Stage 0 = normal
• stage I = isolated bilateral thoracic lymphadenopathy
• Stage II = bilateral hillar lymphadenopathy plus lung parenchymal infiltration
• Stage III = parenchymal infiltration
• Stage IV = advanced parenchymal disease, including overt pulmonary fibrosis

Question 4

what are the pulmonary symptoms of sarcodosis

Answer 4

• Hemoptysis
• shortness of breath
• dry cough
• wheezing
• pain in the chest

Question 5

Describe the lymph node findings in Sarcodosis

Answer 5

• lymph nodes are enlarged tender lymph nodes (present within the neck, chest, chin, armpits, and groin)

Question 6

what are the dermatologic manifestations of sarcodosis

Answer 6

• various types of bumps, ulcers that are usually itchy
• painful bumps (at the ankles and shin) known as ERYTHEMA NODOSUM
• difiguring sores (nasal passages, cheeks, ears, eyelids, and fingers) CALLED LUPUS PERNIO

Question 7

describe ocular involvmeent of sarcodosis

Answer 7

• Optic neuritis
• keratoconjunctivitis
• uveitis

Question 8

describe tx goals

Answer 8

• management of systemic manifestations (improve organ function, relieve symptoms, sfrink granulomas)
• Meds = prednisone, plaquenil, nsaids, cyclophosphamide etc