Basic Science Concepts Flashcards

Chapter 2

1
Q

What is the Central Nervous System made up of and how does it work?

A
  • CNS = Brain and Spine that send signals to the Peripheral Nervous System [PNS]
  • PNS = Somatic NS which is voluntary & Autonomic NS is involuntary
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2
Q

What are Neurotransmitter?

A
  • Chemical Messengers that carry signals in the body
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3
Q

What are some of the Common Neurotransmitter in the body>

A
  • Acetylcholine
  • Epinephrine
  • Norepinephrine
  • Dopamine
  • Serotonin
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4
Q

Where is Ach mainly used at?

A
  • Within Somatic NS; released by Nicotinic Receptors in Skeletal Mucsle
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5
Q

What are the two pathways of the Autonomic NS?

A
  • Parasympathetic NS
  • Sympathetic NS
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6
Q

What is the Parasympathetic NS and how does it wouk?

A
  • “Rest & Digest”
  • Releasing Ach that bind to muscarinc receptors in the body
  • Causes SLUDD
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7
Q

What is SLUDD within the Parasympathethic NS?

A
  • Salivation
  • Lacrimation
  • Urinatoin
  • Defection
  • Digestion
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8
Q

What is the Sympathetic NS and how does it work?

A
  • “Fight or Flight”
  • Releasing Epi and NE that binds to Beta-1, -2, Alpha-1 receptors
  • Causing Increased BP, HR, Bronchodilation
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9
Q

What can Substrates be?

A
  • Endogenous [from self]
  • Exogenous [outside self]
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10
Q

What is the difference between Agonist and Antagonist

A
  • Agoinst [activate]
  • Antagonist [inhibit]
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11
Q

What aer the Two types of interactions of Antagonists?

A
  • Competitive [binds at the site]
  • Noncompetitive [binds at a place other than the site]
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12
Q

What are some of the common receptors and there substrates

A
  • Muscarinic — Ach
  • Nicotine — Ach
  • Alpha-1[Preripheral] — Epi, NE
  • Alpha-2 [Brain] — Epi, NE
  • Beta-1 [Heart] — Epi, NE
  • Beta-2 [Lung] — Epi
  • Dopamine — Dop
  • Serotonin — Serotonin
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13
Q

What are Enzymes

A
  • compounds that speed up a reaction

MAO are a good example of Enzymes [breaking down catecholamines in teh pathyway]

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14
Q

What are some of the common enzymes?

A
  • Acetylcholinesterase
  • Angiotension-Converting Enzyme
  • Catechol-O-Methylransferase
  • Cyclooxygenase
  • Monoamine Oxidase
  • Phophodiesterase
  • Vitamin K Epoxide Reductase
  • Xanthine Oxidase
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15
Q

What is the Endogenous Effect of Acetylcholinesterase?

A
  • Break down Ach
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16
Q

What is the Endogenous Effect of Angiotensin-Converting Enzyme?

A
  • Blocks Ang I to Ang II
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17
Q

What is the Endogenous Effect of Catechol-O-Methyltransferase?

A
  • Breaks down Levodopa
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18
Q

What is the Endogenous Effect of Cyclooxygenase?

A
  • Converts arachidonic acid to prostaglandin and Tromboxane A2 [causes inflammation and platelet aggregation]
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19
Q

What is the Endogenous Effect of Monoamine Oxidase?

A
  • Breaks down Catecholamines [Epi, NE, Dopa…]
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20
Q

What is the Endogenous Effect of Phosphodiesterase?

A
  • Breaks down cGMP [smooth muscle relaxant]
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21
Q

What is the Endogenous Effect of Vitamin K Epoxide Reductase?

A
  • Makes Vitamin K into its active form [blood clotting]
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22
Q

What is the Endogenous Effect of Xanthine Oxidase?

A
  • Breaks down hypoxanthine into xanthine then into uric acid [allopurinol stops this]
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23
Q

What is this Structure

A
  • Hydroxyl or Alcohol
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24
Q

What is this Structure

A
  • Ketone
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25
Q

What is this Structure

A
  • Aldehyde
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26
Q

What is this Structure

27
Q

What is this Structure

28
Q

What is this Structure

29
Q

What is this Structure

A
  • Aromatic [Benzene Ring]
30
Q

What is this Structure

31
Q

What is this Structure

32
Q

What is this Structure

33
Q

What is this Structure

34
Q

What is this Structure

35
Q

What is this Structure

36
Q

What is this Structure

37
Q

What is this Structure

38
Q

What is this Structure

A
  • Sulfonamide
39
Q

What is this Structure

A
  • Amine [Primary]
40
Q

What is this Structure

A
  • Amine [Tertiary]
41
Q

What is this Structure

42
Q

What is this Structure

43
Q

What is this Essential Drug Structure and what is important about it?

A
  • Amoxicillin
  • Beta-Lactam, Penicillin [Beta-Lactam Ring with 5-sided ring]
44
Q

What is this Essential Drug Structure and what is important about it?

A
  • Ceftriaxone
  • Beta-Lactam, Cephalosporin [Beta-Lactam Ring with 6-sided Ring]
45
Q

What is this Essential Drug Structure and what is important about it?

A
  • Ertapenem
  • Beta-Latacm, Carbapenem [Beta-Lactam Ring with 5-sided ring]
46
Q

What is this Essential Drug Structure and what is important about it?

A
  • Aztreonam
  • Monobactam [1 Lactam ring]
47
Q

What is this Essential Drug Structure and what is important about it?

A
  • Gentamicin
  • Aminoglycoside [has amine and sugar groups]
48
Q

What is this Essential Drug Structure and what is important about it?

A
  • Sulfamethoxazole
  • Sulfonamide ABX [has sulfoamide group]
48
Q

What is this Essential Drug Structure and what is important about it?

A
  • Aspirin
  • Salicylate NSAID [Acidic and Carboxyl group]
49
Q

What is this Essential Drug Structure and what is important about it?

A
  • Ibuprofen
  • NSAID [carboxyl group]
50
Q

What is this Essential Drug Structure and what is important about it?

A
  • Amphetamine
  • Stimulant [has amine group]
51
Q

What is this Essential Drug Structure and what is important about it?

A
  • Levothyroxine
  • T4 [contain Iodine; 4 for T4 and 3 for T3]
52
Q

What is this Essential Drug Structure and what is important about it?

A
  • Aminodarone
  • Class III antiarrhythmic [2 Iodines]
53
Q

What is this Essential Drug Structure and what is important about it?

A
  • Fenofibrate
  • Fibrate [for cholesterol - contains ketone group]
54
Q

What is this Essential Drug Structure and what is important about it?

A
  • Amitriptyline
  • TCA [3 rings]
55
Q

What is this Essential Drug Structure and what is important about it?

A
  • Chlorpromazine
  • Antipsych [thioether group]
56
Q

What is Stability?

A
  • how the product remains during a time peroid of storage use
57
Q

What are the 3 types of degradatin?

A
  • RedOx
  • Hydrolysis
  • Photolysis
58
Q

What is Oxidation/Reduction

A
  • Red [gain electrons] & Ox [loss electrions]
  • Most common Oxidation occurs with hydroxyl groups

Some compounds change color when oxidized [Epi becomes yellowish/orange]

59
Q

What are some way to Prevent Oxidation or Reduction?

A
  • Light Protections [Amber vials], Temperature Control, Antioxidants [ascorbic acids], Chelating Agents [EDTA], pH Control [using a buffer]
60
Q

What is Hydrolysis

A
  • When water causes a cleavge of a bond
  • Most commonly with Esters, Amides, Lactams
61
Q

What is Photolysis

A
  • UV light exposure that causes degradation
  • Prevented with light protection
  • Ascorbic Acid, Nitropruside, Phytonadione are sensitive to light