Basal Ganglia Flashcards
BG fxn
initiate mvmts
parts of BG
striatum (caudate N. and putamen)
globus pallidus (in/ex)
substantia nigra
subthalamic N
parts of BG origins
striatum (telencephalon)
GP (telen)
SN (mid)
subthalamic (dien)
BG lesion (side)
contralateral
Parkinson’s path
lewy bodies (defect in folding) loss of pigmented dopa-neurons from SN underactive motor cortex
most common BG disease
parkinsons
parkinsons Sx
“poverty of mvmt”
Parkinson’s path
lewy bodies (defect in folding)
loss of pigmented dopa-neurons from SN
direct pathway lesion –>
underactive motor cortex
parkinsons Sx
“poverty of mvmt”
bradykinesia, pill-rolling (resting) tremor
shuffling gate
stooped posture
huntington disease mech
indirect path is lesioned
can’t suppress unwanted mvmt
CAG repeat
huntington disease mech
indirect path is lesioned can't suppress unwanted mvmt CAG repeat degen of GABA neurons in striatum atrophy of caudate nuc
huntingtons sx
chorea (@ rest not when doing things)
personality cchanges
dementia
wilsons disease mech
both paths involved
copper accumulation
lesions in putamen
wilsons sx
wing beating tremor
parkinsons, chorea, liver
hemiballism mech
destroy STN
indirect pathway lesion
overactive motor cortex
